HGFA Is an Injury-Regulated Systemic Factor That Induces the Transition of Stem Cells into G

Overview

Journal Cell Rep

Publisher Cell Press

Specialties Biology
Cell Biology
Molecular Biology

Date 2017 Apr 20

PMID 28423312

Citations 84

Authors

Joseph T Rodgers

Matthew D Schroeder

Chanthia Ma

Thomas A Rando

Affiliations

Soon will be listed here.

Abstract

The activation of quiescent stem cells into the cell cycle is a key step in initiating the process of tissue repair. We recently reported that quiescent stem cells can transition into G, a cellular state in which they have an increased functional ability to activate and participate in tissue repair. However, the precise molecular signals that induce G in stem cells have remained elusive. Here, we show that the injury-induced regulation of hepatocyte growth factor (HGF) proteolytic processing via the systemic protease, hepatocyte growth factor activator (HGFA), stimulates G in skeletal muscle stem cells (MuSCs) and fibro-adipogenic progenitors (FAPs). We demonstrate that administering active HGFA to animals is sufficient to induce G in stem cells throughout the body and to significantly accelerate the processes of stem cell activation and tissue repair. Our data suggest that factors that induce G will have broad therapeutic applications for regenerative medicine and wound healing.

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