Thrombin Signalling and Protease-activated Receptors

Overview

Journal Nature

Specialty Science

Date 2000 Sep 23

PMID 11001069

Citations 786

Authors

S R Coughlin

Affiliations

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Abstract

How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.

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