Circular RNAs in Human Cancer

Overview

Journal Mol Cancer

Publisher Biomed Central

Specialties Molecular Biology
Oncology

Date 2017 Feb 2

PMID 28143578

Citations 226

Authors

Yumin Wang

Yongzhen Mo

Zhaojian Gong

Xiang Yang

Mo Yang

Shanshan Zhang

Fang Xiong

Bo Xiang

Ming Zhou

Qianjin Liao

Wenling Zhang

Xiayu Li

Xiaoling Li

Yong Li

Guiyuan Li

Zhaoyang Zeng

Wei Xiong

Affiliations

Soon will be listed here.

Abstract

CircRNAs are a novel type of RNAs. With the newly developed technology of next-generation sequencing (NGS), especially RNA-seq technology, over 30,000 circRNAs have already been found. Owing to their unique structure, they are more stable than linear RNAs. CircRNAs play important roles in the carcinogenesis of cancer. The expression of circRNAs is correlated with patients' clinical characteristics, and circRNAs play a vital role in many aspects of malignant phenotypes, including cell cycle, apoptosis, vascularization, and invasion; metastasis as a RNA sponge, binding to RBP; or translation. Therefore, it is meaningful to further study the mechanism of interactions between circRNAs and tumors. The role of circRNAs as molecular markers or potential targets will provide promising application perspectives, such as early tumor diagnosis, therapeutic evaluation, prognosis prediction, and even gene therapy for tumors.

Citing Articles

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Role of circular RNAs in cancer therapy resistance.

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