Exploring CeRNA Networks for Key Biomarkers in Breast Cancer Subtypes and Immune Regulation

Overview

Journal Sci Rep

Specialty Science

Date 2023 Nov 27

PMID 38012271

Authors

Alireza Shariatmadar Taleghani

Yasaman Zohrab Beigi

Fatemeh Zare-Mirakabad

Ali Masoudi-Nejad

Affiliations

Soon will be listed here.

Abstract

Breast cancer is a major global health concern, and recent researches have highlighted the critical roles of non-coding RNAs in both cancer and the immune system. The competing endogenous RNA hypothesis suggests that various types of RNA, including coding and non-coding RNAs, compete for microRNA targets, acting as molecular sponges. This study introduces the Pre_CLM_BCS pipeline to investigate the potential of long non-coding RNAs and circular RNAs as biomarkers in breast cancer subtypes. The pipeline identifies specific modules within each subtype that contain at least one long non-coding RNA or circular RNA exhibiting significantly distinct expression patterns when compared to other subtypes. The results reveal potential biomarker genes for each subtype, such as circ_001845, circ_001124, circ_003925, circ_000736, and circ_003996 for the basal-like subtype, circ_00306 and circ_00128 for the luminal B subtype, circ_000709 and NPHS1 for the normal-like subtype, CAMKV and circ_001855 for the luminal A subtype, and circ_00128 and circ_00173 for the HER2+ subtype. Additionally, certain long non-coding RNAs and circular RNAs, including RGS5-AS1, C6orf223, HHLA3-AS1, circ_000349, circ_003996, circ_003925, circ_002665, circ_001855, and DLEU1, are identified as potential regulators of T cell mechanisms, underscoring their importance in understanding breast cancer progression in various subtypes. This pipeline provides valuable insights into cancer and immune-related processes in breast cancer subtypes.

Citing Articles

The role of ceRNAs in breast cancer microenvironmental regulation and therapeutic implications.

Yilmaz A, Ari Yuka S J Mol Med (Berl). 2024; 103(1):33-49.

PMID: 39641797 DOI: 10.1007/s00109-024-02503-y.

Competing endogenous RNAs (ceRNAs) and drug resistance to cancer therapy.

To K, Zhang H, Cho W Cancer Drug Resist. 2024; 7:37.

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