CMOS Electrochemical Instrumentation for Biosensor Microsystems: A Review

Overview

Journal Sensors (Basel)

Publisher MDPI

Specialty Biotechnology

Date 2017 Jan 3

PMID 28042860

Citations 45

Authors

Haitao Li

Xiaowen Liu

Lin Li

Xiaoyi Mu

Roman Genov

Andrew J Mason

Affiliations

Soon will be listed here.

Abstract

Modern biosensors play a critical role in healthcare and have a quickly growing commercial market. Compared to traditional optical-based sensing, electrochemical biosensors are attractive due to superior performance in response time, cost, complexity and potential for miniaturization. To address the shortcomings of traditional benchtop electrochemical instruments, in recent years, many complementary metal oxide semiconductor (CMOS) instrumentation circuits have been reported for electrochemical biosensors. This paper provides a review and analysis of CMOS electrochemical instrumentation circuits. First, important concepts in electrochemical sensing are presented from an instrumentation point of view. Then, electrochemical instrumentation circuits are organized into functional classes, and reported CMOS circuits are reviewed and analyzed to illuminate design options and performance tradeoffs. Finally, recent trends and challenges toward on-CMOS sensor integration that could enable highly miniaturized electrochemical biosensor microsystems are discussed. The information in the paper can guide next generation electrochemical sensor design.

Citing Articles

Surface-modified CMOS biosensors.

Dehghandehnavi F, Sajal M, Dandin M Front Bioeng Biotechnol. 2024; 12:1441430.

PMID: 39569164 PMC: 11576298. DOI: 10.3389/fbioe.2024.1441430.

Sensors in Bone: Technologies, Applications, and Future Directions.

Anwar A, Kaur T, Chaugule S, Yang Y, Mago A, Shim J Sensors (Basel). 2024; 24(19).

PMID: 39409211 PMC: 11478373. DOI: 10.3390/s24196172.

Ultrasensitive Hierarchical AuNRs@SiO@Ag SERS Probes for Enrichment and Detection of Insulin and C-Peptide in Serum.

Zhang T, Wu H, Qiu C, Wang M, Wang H, Zhu S Int J Nanomedicine. 2024; 19:6281-6293.

PMID: 38919772 PMC: 11198011. DOI: 10.2147/IJN.S462601.

Wide Voltage Swing Potentiostat with Dynamic Analog Ground to Expand Electrochemical Potential Windows in Integrated Microsystems.

Ashoori E, Goderis D, Inohara A, Mason A Sensors (Basel). 2024; 24(9).

PMID: 38733006 PMC: 11086346. DOI: 10.3390/s24092902.

Rapid detection of carcinoembryonic antigen by means of an electrochemical aptasensor.

Yunussova N, Tilegen M, Pham T, Kanayeva D iScience. 2024; 27(5):109637.

PMID: 38646165 PMC: 11033162. DOI: 10.1016/j.isci.2024.109637.

References

Manickam A, Chevalier A, McDermott M, Ellington A, Hassibi A . A CMOS Electrochemical Impedance Spectroscopy (EIS) Biosensor Array. IEEE Trans Biomed Circuits Syst. 2013; 4(6):379-90. DOI: 10.1109/TBCAS.2010.2081669. View

Huang Y, Mason A . Lab-on-CMOS integration of microfluidics and electrochemical sensors. Lab Chip. 2013; 13(19):3929-34. PMC: 3793889. DOI: 10.1039/c3lc50437a. View

Nazari M, Mazhab-Jafari H, Leng L, Guenther A, Genov R . CMOS neurotransmitter microarray: 96-channel integrated potentiostat with on-die microsensors. IEEE Trans Biomed Circuits Syst. 2013; 7(3):338-48. DOI: 10.1109/TBCAS.2012.2203597. View

Ahmadi M, Jullien G . A wireless-implantable microsystem for continuous blood glucose monitoring. IEEE Trans Biomed Circuits Syst. 2013; 3(3):169-80. DOI: 10.1109/TBCAS.2009.2016844. View

Weerakoon P, Culurciello E, Klemic K, Sigworth F . An integrated patch-clamp potentiostat with electrode compensation. IEEE Trans Biomed Circuits Syst. 2013; 3(2):117-25. DOI: 10.1109/TBCAS.2008.2005419. View

Ruan C, Yang L, Li Y . Immunobiosensor chips for detection of Escherichia coil O157:H7 using electrochemical impedance spectroscopy. Anal Chem. 2002; 74(18):4814-20. DOI: 10.1021/ac025647b. View

Lee S, Sawada K, Takao H, Ishida M . An enhanced glucose biosensor using charge transfer techniques. Biosens Bioelectron. 2008; 24(4):650-6. DOI: 10.1016/j.bios.2008.06.014. View

Rahman M, Kwon N, Won M, Choe E, Shim Y . Functionalized conducting polymer as an enzyme-immobilizing substrate: an amperometric glutamate microbiosensor for in vivo measurements. Anal Chem. 2005; 77(15):4854-60. DOI: 10.1021/ac050558v. View

Li H, Boling C, Mason A . CMOS Amperometric ADC With High Sensitivity, Dynamic Range and Power Efficiency for Air Quality Monitoring. IEEE Trans Biomed Circuits Syst. 2016; 10(4):817-27. PMC: 5056750. DOI: 10.1109/TBCAS.2016.2571306. View

10.

Niitsu K, Ota S, Gamo K, Kondo H, Hori M, Nakazato K . Development of Microelectrode Arrays Using Electroless Plating for CMOS-Based Direct Counting of Bacterial and HeLa Cells. IEEE Trans Biomed Circuits Syst. 2015; 9(5):607-19. DOI: 10.1109/TBCAS.2015.2479656. View

11.

Rosenstein J, Wanunu M, Merchant C, Drndic M, Shepard K . Integrated nanopore sensing platform with sub-microsecond temporal resolution. Nat Methods. 2012; 9(5):487-92. PMC: 3648419. DOI: 10.1038/nmeth.1932. View

12.

Maalouf R, Fournier-Wirth C, Coste J, Chebib H, Saikali Y, Vittori O . Label-free detection of bacteria by electrochemical impedance spectroscopy: comparison to surface plasmon resonance. Anal Chem. 2007; 79(13):4879-86. DOI: 10.1021/ac070085n. View

13.

Crescentini M, Bennati M, Carminati M, Tartagni M . Noise limits of CMOS current interfaces for biosensors: a review. IEEE Trans Biomed Circuits Syst. 2014; 8(2):278-92. DOI: 10.1109/TBCAS.2013.2262998. View

14.

Ayers S, Gillis K, Lindau M, Minch B . Design of a CMOS Potentiostat Circuit for Electrochemical Detector Arrays. IEEE Trans Circuits Syst I Regul Pap. 2010; 54(4):736-744. PMC: 2877523. DOI: 10.1109/TCSI.2006.888777. View

15.

Cai W, Peck J, van der Weide D, Hamers R . Direct electrical detection of hybridization at DNA-modified silicon surfaces. Biosens Bioelectron. 2004; 19(9):1013-9. DOI: 10.1016/j.bios.2003.09.009. View

16.

Bontidean I, Berggren C, Johansson G, Csoregi E, Mattiasson B, Lloyd J . Detection of heavy metal ions at femtomolar levels using protein-based biosensors. Anal Chem. 1998; 70(19):4162-9. DOI: 10.1021/ac9803636. View

17.

Peters J, Miner L, Michael A, Sesack S . Ultrastructure at carbon fiber microelectrode implantation sites after acute voltammetric measurements in the striatum of anesthetized rats. J Neurosci Methods. 2004; 137(1):9-23. DOI: 10.1016/j.jneumeth.2004.02.006. View

18.

Stefan R, van Staden J, Aboul-Enein H . Immunosensors in clinical analysis. Fresenius J Anal Chem. 2001; 366(6-7):659-68. DOI: 10.1007/s002160051560. View

19.

Guo J, Ng W, Yuan J, Li S, Chan M . A 200-Channel Area-Power-Efficient Chemical and Electrical Dual-Mode Acquisition IC for the Study of Neurodegenerative Diseases. IEEE Trans Biomed Circuits Syst. 2015; 10(3):567-78. DOI: 10.1109/TBCAS.2015.2468052. View

20.

Ponzio F, Jonsson G . A rapid and simple method for the determination of picogram levels of serotonin in brain tissue using liquid chromatography with electrochemical detection. J Neurochem. 1979; 32(1):129-32. DOI: 10.1111/j.1471-4159.1979.tb04519.x. View