Surface-modified CMOS Biosensors

Overview

Journal Front Bioeng Biotechnol

Date 2024 Nov 21

PMID 39569164

Authors

Fahimeh Dehghandehnavi

Md Sakibur Sajal

Marc Dandin

Affiliations

Soon will be listed here.

Abstract

Biosensors translate biological events into electronic signals that quantify biological processes. They are increasingly used in diagnostics applications that leverage their ability to process small sample volumes. One recent trend has been to integrate biosensors with complementary metal-oxide-semiconductor (CMOS) chips to provide enhanced miniaturization, parallel sensing, and low power consumption at a low cost. CMOS-enabled biosensors are used in monitoring DNA hybridization, enzymatic reactions, and cell proliferation, to name a few applications. This paper explores the materials and processes used in emerging CMOS biosensors. We discuss subtractive and additive processes for creating electrodes for electrochemical sensing applications. We discuss functionalization techniques for creating bioelectronic interfaces that allow molecular events to be transduced into the electrical domain using a plurality of modalities that are readily provided by CMOS chips. Example modalities featured are optical sensing, electrochemical detection, electrical detection, magnetic sensing, and mechanical sensing.

References

Stadler V, Beyer M, Konig K, Nesterov A, Torralba G, Lindenstruth V . Multifunctional CMOS microchip coatings for protein and peptide arrays. J Proteome Res. 2007; 6(8):3197-202. DOI: 10.1021/pr0701310. View

Wicks S, Hargrove A . Fluorescent indicator displacement assays to identify and characterize small molecule interactions with RNA. Methods. 2019; 167:3-14. PMC: 6756977. DOI: 10.1016/j.ymeth.2019.04.018. View

Balasaheb Nimse S, Song K, Sonawane M, Rafiq Sayyed D, Kim T . Immobilization techniques for microarray: challenges and applications. Sensors (Basel). 2014; 14(12):22208-29. PMC: 4299010. DOI: 10.3390/s141222208. View

Sigvardson K, Birks J . Detection of nitro-polycyclic aromatic hydrocarbons in liquid chromatography by zinc reduction and peroxyoxalate chemiluminescence. J Chromatogr. 1984; 316:507-18. DOI: 10.1016/s0021-9673(00)96179-x. View

Forouhi S, Ghafar-Zadeh E . Applications of CMOS Devices for the Diagnosis and Control of Infectious Diseases. Micromachines (Basel). 2020; 11(11). PMC: 7698050. DOI: 10.3390/mi11111003. View

Fellin T, Pascual O, Haydon P . Astrocytes coordinate synaptic networks: balanced excitation and inhibition. Physiology (Bethesda). 2006; 21:208-15. DOI: 10.1152/physiol.00161.2005. View

Wang A, Sheng Y, Li W, Jung D, Junek G, Liu H . A Multimodal and Multifunctional CMOS Cellular Interfacing Array for Digital Physiology and Pathology Featuring an Ultra Dense Pixel Array and Reconfigurable Sampling Rate. IEEE Trans Biomed Circuits Syst. 2022; 16(6):1057-1074. DOI: 10.1109/TBCAS.2022.3224064. View

Singh N, Thungon P, Estrela P, Goswami P . Development of an aptamer-based field effect transistor biosensor for quantitative detection of Plasmodium falciparum glutamate dehydrogenase in serum samples. Biosens Bioelectron. 2018; 123:30-35. DOI: 10.1016/j.bios.2018.09.085. View

Huang M, Dorta-Quinones C, Minch B, Lindau M . On-Chip Cyclic Voltammetry Measurements Using a Compact 1024-Electrode CMOS IC. Anal Chem. 2021; 93(22):8027-8034. PMC: 8650766. DOI: 10.1021/acs.analchem.1c01132. View

10.

Mosharov E, Sulzer D . Analysis of exocytotic events recorded by amperometry. Nat Methods. 2005; 2(9):651-8. DOI: 10.1038/nmeth782. View

11.

Kumashi S, Jung D, Park J, Tejedor-Sanz S, Grijalva S, Wang A . A CMOS Multi-Modal Electrochemical and Impedance Cellular Sensing Array for Massively Paralleled Exoelectrogen Screening. IEEE Trans Biomed Circuits Syst. 2021; 15(2):221-234. DOI: 10.1109/TBCAS.2021.3068710. View

12.

Mirsian S, Khodadadian A, Hedayati M, Manzour-Ol-Ajdad A, Kalantarinejad R, Heitzinger C . A new method for selective functionalization of silicon nanowire sensors and Bayesian inversion for its parameters. Biosens Bioelectron. 2019; 142:111527. DOI: 10.1016/j.bios.2019.111527. View

13.

Hassibi A, Vikalo H, Riechmann J, Hassibi B . Real-time DNA microarray analysis. Nucleic Acids Res. 2009; 37(20):e132. PMC: 2802827. DOI: 10.1093/nar/gkp675. View

14.

Costa T, Cardoso F, Germano J, Freitas P, Piedade M . A CMOS Front-End With Integrated Magnetoresistive Sensors for Biomolecular Recognition Detection Applications. IEEE Trans Biomed Circuits Syst. 2017; 11(5):988-1000. DOI: 10.1109/TBCAS.2017.2743685. View

15.

Strianese M, Staiano M, Ruggiero G, Labella T, Pellecchia C, DAuria S . Fluorescence-based biosensors. Methods Mol Biol. 2012; 875:193-216. DOI: 10.1007/978-1-61779-806-1_9. View

16.

Hofmann A, Meister M, Rolapp A, Reich P, Scholz F, Schafer E . Light Absorption Measurement With a CMOS Biochip for Quantitative Immunoassay Based Point-of-Care Applications. IEEE Trans Biomed Circuits Syst. 2021; 15(3):369-379. DOI: 10.1109/TBCAS.2021.3083359. View

17.

Koizumi S, Fujishita K, Tsuda M, Shigemoto-Mogami Y, Inoue K . Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures. Proc Natl Acad Sci U S A. 2003; 100(19):11023-8. PMC: 196920. DOI: 10.1073/pnas.1834448100. View

18.

Krivitsky V, Zverzhinetsky M, Krivitsky A, Hsiung L, Naddaka V, Gabriel I . Cellular Metabolomics by a Universal Redox-Reactive Nanosensors Array: From the Cell Level to Tumor-on-a-Chip Analysis. Nano Lett. 2019; 19(4):2478-2488. DOI: 10.1021/acs.nanolett.9b00052. View

19.

Cao X, Li L, Wang Q, Wu Q, Hu H, Zhang M . Astrocyte-derived ATP modulates depressive-like behaviors. Nat Med. 2013; 19(6):773-7. DOI: 10.1038/nm.3162. View

20.

Huang C, Huang Y, Yen P, Tsai H, Liao H, Juang Y . A CMOS wireless biomolecular sensing system-on-chip based on polysilicon nanowire technology. Lab Chip. 2013; 13(22):4451-9. DOI: 10.1039/c3lc50798j. View