Rational Design of Materials Interface for Efficient Capture of Circulating Tumor Cells

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2016 Dec 17

PMID 27980914

Citations 13

Authors

Yong-Qiang Li

Bevita K Chandran

Chwee Teck Lim

Xiaodong Chen

Affiliations

Soon will be listed here.

Abstract

Originating from primary tumors and penetrating into blood circulation, circulating tumor cells (CTCs) play a vital role in understanding the biology of metastasis and have great potential for early cancer diagnosis, prognosis and personalized therapy. By exploiting the specific biophysical and biochemical properties of CTCs, various material interfaces have been developed for the capture and detection of CTCs from blood. However, due to the extremely low number of CTCs in peripheral blood, there exists a need to improve the efficiency and specificity of the CTC capture and detection. In this regard, a critical review of the numerous reports of advanced platforms for highly efficient and selective capture of CTCs, which have been spurred by recent advances in nanotechnology and microfabrication, is essential. This review gives an overview of unique biophysical and biochemical properties of CTCs, followed by a summary of the key material interfaces recently developed for improved CTC capture and detection, with focus on the use of microfluidics, nanostructured substrates, and miniaturized nuclear magnetic resonance-based systems. Challenges and future perspectives in the design of material interfaces for capture and detection of CTCs in clinical applications are also discussed.

Citing Articles

Digital Quantitative Detection for Heterogeneous Protein and mRNA Expression Patterns in Circulating Tumor Cells.

Li H, Li J, Zhang Z, Yang Q, Du H, Dong Q Adv Sci (Weinh). 2024; 12(2):e2410120.

PMID: 39556692 PMC: 11727120. DOI: 10.1002/advs.202410120.

Conductive Nanofibers-Enhanced Microfluidic Device for the Efficient Capture and Electrical Stimulation-Triggered Rapid Release of Circulating Tumor Cells.

Huang Y, Li X, Hou J, Luo Z, Yang G, Zhou S Biosensors (Basel). 2023; 13(5).

PMID: 37232858 PMC: 10216647. DOI: 10.3390/bios13050497.

Leukocyte Depletion and Size-Based Enrichment of Circulating Tumor Cells Using a Pressure-Sensing Microfiltration Device.

Onoshima D, Hase T, Kihara N, Kuboyama D, Tanaka H, Ozawa N ACS Meas Sci Au. 2023; 3(2):113-119.

PMID: 37090261 PMC: 10120030. DOI: 10.1021/acsmeasuresciau.2c00057.

Well-Defined Nanostructured Biointerfaces: Strengthened Cellular Interaction for Circulating Tumor Cells Isolation.

Yu L, Tang P, Nie C, Hou Y, Haag R Adv Healthc Mater. 2021; 10(11):e2002202.

PMID: 33943037 PMC: 11468763. DOI: 10.1002/adhm.202002202.

3D printed microfluidic devices for circulating tumor cells (CTCs) isolation.

Chen J, Liu C, Wang X, Sweet E, Liu N, Gong X Biosens Bioelectron. 2019; 150:111900.

PMID: 31767348 PMC: 9266647. DOI: 10.1016/j.bios.2019.111900.

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