Nanomaterial-based Microfluidic Chips for the Capture and Detection of Circulating Tumor Cells

Overview

Journal Nanotheranostics

Specialty Biotechnology

Date 2017 Oct 27

PMID 29071201

Citations 10

Authors

Duanping Sun

Zuanguang Chen

Minhao Wu

Yuanqing Zhang

Affiliations

Soon will be listed here.

Abstract

Circulating tumor cells (CTCs), a type of cancer cells that spreads from primary or metastatic tumors into the bloodstream, can lead to a new fatal metastasis. As a new type of liquid biopsy, CTCs have become a hot pursuit and detection of CTCs offers the possibility for early diagnosis of cancers, earlier evaluation of chemotherapeutic efficacy and cancer recurrence, and choice of individual sensitive anti-cancer drugs. The fundamental challenges of capturing and characterizing CTCs are the extremely low number of CTCs in the blood and the intrinsic heterogeneity of CTCs. A series of microfluidic devices have been proposed for the analysis of CTCs with automation capability, precise flow behaviors, and significant advantages over the conventional larger scale systems. This review aims to provide in-depth insights into CTCs analysis, including various nanomaterial-based microfluidic chips for the capture and detection of CTCs based on the specific biochemical and physical properties of CTCs. The current developmental trends and promising research directions in the establishment of microfluidic chips for the capture and detection of CTCs are also discussed.

Citing Articles

Tumor-on-chip platforms for breast cancer continuum concept modeling.

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The Role of Circulating Tumor Cells as a Liquid Biopsy for Cancer: Advances, Biology, Technical Challenges, and Clinical Relevance.

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Recent advances in micro-/nanostructure array integrated microfluidic devices for efficient separation of circulating tumor cells.

Kang H, Xiong Y, Ma L, Yang T, Xu X RSC Adv. 2022; 12(54):34892-34903.

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Nanomaterial-assisted microfluidics for multiplex assays.

Wang Y, Gao Y, Yin Y, Pan Y, Wang Y, Song Y Mikrochim Acta. 2022; 189(4):139.

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Progress and application of circulating tumor cells in non-small cell lung cancer.

Qian H, Zhang Y, Xu J, He J, Gao W Mol Ther Oncolytics. 2021; 22:72-84.

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