Animal Models of Frailty: Current Applications in Clinical Research

Overview

Journal Clin Interv Aging

Publisher Dove Medical Press

Specialty Geriatrics

Date 2016 Nov 9

PMID 27822024

Citations 27

Authors

Alice E Kane

Sarah N Hilmer

John Mach

Sarah J Mitchell

Rafael de Cabo

Susan E Howlett

Affiliations

Soon will be listed here.

Abstract

The ethical, logistical, and biological complications of working with an older population of people inherently limits clinical studies of frailty. The recent development of animal models of frailty, and tools for assessing frailty in animal models provides an invaluable opportunity for frailty research. This review summarizes currently published animal models of frailty including the interleukin-10 knock-out mouse, the mouse frailty phenotype assessment tool, and the mouse clinical frailty index. It discusses both current and potential roles of these models in research into mechanisms of frailty, interventions to prevent/delay frailty, and the effect of frailty on outcomes. Finally, this review discusses some of the challenges and opportunities of translating research findings from animals to humans.

Citing Articles

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Hilmer S, Johnell K, Mach J Drugs Aging. 2024; 41(8):633-640.

PMID: 38982010 PMC: 11322264. DOI: 10.1007/s40266-024-01129-6.

Association of intrinsic capacity with functional ability, sarcopenia and systemic inflammation in pre-frail older adults.

Merchant R, Chan Y, Anbarasan D, Vellas B Front Med (Lausanne). 2024; 11:1374197.

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Exploring In Vivo Models of Musculoskeletal Frailty: A Comprehensive Systematic Review.

Contartese D, Di Sarno L, Salamanna F, Martini L, Fini M, Giavaresi G Int J Mol Sci. 2023; 24(23).

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Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.

Wu T, Pelus L, Plett P, Sampson C, Chua H, Fisher A Radiat Res. 2023; 199(5):468-489.

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Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging.

El Assar M, Alvarez-Bustos A, Sosa P, Angulo J, Rodriguez-Manas L Int J Mol Sci. 2022; 23(15).

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