Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits

Overview

Journal Cell Rep

Publisher Cell Press

Specialties Biology
Cell Biology
Molecular Biology

Date 2016 Nov 8

PMID 27818087

Citations 99

Authors

Raul Aguirre-Gamboa

Irma Joosten

Paulo C M Urbano

Renate G van der Molen

Esther van Rijssen

Bram van Cranenbroek

Marije Oosting

Sanne Smeekens

Martin Jaeger

Maria Zorro

Sebo Withoff

Antonius E van Herwaarden

Fred C G J Sweep

Romana T Netea

Morris A Swertz

Lude Franke

Ramnik J Xavier

Leo A B Joosten

Mihai G Netea

Cisca Wijmenga

Vinod Kumar

Yang Li

Hans J P M Koenen

Affiliations

Soon will be listed here.

Abstract

Effective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors. We used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell populations in peripheral blood, including associations with immunoglobulin concentrations, from ∼500 healthy volunteers from the Human Functional Genomics Project. Genetic heritability estimation showed that variations in T cell numbers are more strongly driven by genetic factors, while B cell counts are more environmentally influenced. Quantitative trait loci (QTL) mapping identified eight independent genomic loci associated with leukocyte count variation, including four associations with T and B cell subtypes. The QTLs identified were enriched among genome-wide association study (GWAS) SNPs reported to increase susceptibility to immune-mediated diseases. Our systems approach provides insights into cellular and humoral immune trait variability in humans.

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