IL-6 Trans-signaling is Essential for the Development of Hepatocellular Carcinoma in Mice

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2016 Oct 23

PMID 27770462

Citations 85

Authors

Juri Bergmann

Miryam Muller

Niklas Baumann

Manuel Reichert

Carola Heneweer

Julia Bolik

Karsten Lucke

Sabine Gruber

Antonella Carambia

Susanne Boretius

Ivo Leuschner

Thomas Becker

Bjorn Rabe

Johannes Herkel

F Thomas Wunderlich

Hans-Willi Mittrucker

Stefan Rose-John

Dirk Schmidt-Arras

Affiliations

Soon will be listed here.

Abstract

Conclusion: IL-6 trans-signaling, and not IL-6 classic signaling, is mandatory for development of hepatocellular carcinogenesis. Therefore, specific inhibition of IL-6 trans-signaling, rather than total inhibition of IL-6 signaling, is sufficient to blunt tumor initiation and impair tumor progression without compromising IL-6 classic signaling-driven protective immune responses. (Hepatology 2017;65:89-103).

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