IL-6 Trans-Signaling Is Increased in Diabetes, Impacted by Glucolipotoxicity, and Associated With Liver Stiffness and Fibrosis in Fatty Liver Disease

Overview

Journal Diabetes

Specialty Endocrinology

Date 2023 Sep 27

PMID 37757741

Authors

Aysim Gunes

Clemence Schmitt

Laurent Bilodeau

Catherine Huet

Assia Belblidia

Cindy Baldwin

Jeanne-Marie Giard

Laurent Biertho

Annie Lafortune

Christian Yves Couture

Angela Cheung

Bich N Nguyen

Eithan Galun

Chantal Bemeur

Marc Bilodeau

Mathieu Laplante

An Tang

May Faraj

Jennifer L Estall

Affiliations

Soon will be listed here.

Abstract

Article Highlights: IL-6 and its circulating coreceptor sgp130 are increased in people with fatty liver disease and steatohepatitis. High glucose and lipids stimulated IL-6 and sgp130 secretion from hepatic stellate cells. sgp130 levels correlated with HbA1c, and diabetes concurrent with steatohepatitis further increased circulating levels of all IL-6 trans-signaling mediators. Circulating sgp130 positively correlated with liver stiffness and hepatic fibrosis. Metabolic stress to liver associated with fatty liver disease might shift the balance of IL-6 classical versus trans-signaling, promoting liver fibrosis that is accelerated by diabetes.

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