Extract Alleviates Postprandial Hyperglycemia in Diabetic Mice

Overview

Journal Prev Nutr Food Sci

Date 2016 Oct 19

PMID 27752493

Citations 4

Authors

Sung-In Choi

Mi Hwa Park

Ji-Sook Han

Affiliations

Soon will be listed here.

Abstract

This study was designed to investigate the inhibitory effect of extract against carbohydrate digesting enzymes and its ability to ameliorate postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. extract showed prominent α-glucosidase and α-amylase inhibitory effects. The half-maximal inhibitory concentration (IC) of extract against α-glucosidase and α-amylase was 0.092±0.018 and 0.084±0.027 mg/mL, respectively, suggesting that the α-amylase inhibition activity of the extract was more effective than that of the positive control, acarbose (IC=0.164 mg/mL). The increase in postprandial blood glucose levels was more significantly alleviated in the extract group than in the control group of STZ-induced diabetic mice. Moreover, the area under the curve significantly decreased with extract administration in STZ-induced diabetic mice. These results suggest that extract may help alleviate postprandial hyperglycemia by inhibiting carbohydrate digesting enzymes.

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