Isolation and Identification of Alpha-glucosidase Inhibitors from Tochu-cha (Eucommia Ulmoides)

Overview

Journal Biosci Biotechnol Biochem

Publisher Oxford University Press

Specialties Biochemistry
Biotechnology

Date 1997 Jan 1

PMID 9028049

Citations 36

Authors

J Watanabe

J Kawabata

H Kurihara

R Niki

Affiliations

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Abstract

alpha-Glucosidase inhibitory activity was found in aqueous methanol extracts of tochu-cha, dried leaves of Eucommia ulmoides (Eucommiaceae). Five active principles against yeast enzyme were isolated and characterized. Among them, quercetin (1, Ki: 8.5 x 10(-6) M) was considered to contribute mostly to the activity of the tochu leaves. In regard to an animal alpha-glucosidase, rat intestinal sucrase activity was also inhibited by 1.

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