Non-invasive Diffuse Correlation Tomography Reveals Spatial and Temporal Blood Flow Differences in Murine Bone Grafting Approaches

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2016 Oct 5

PMID 27699097

Citations 10

Authors

Songfeng Han

Ashley R Proctor

Joseph B Vella

Danielle S W Benoit

Regine Choe

Affiliations

Soon will be listed here.

Abstract

Longitudinal blood flow during murine bone graft healing was monitored non-invasively using diffuse correlation tomography. The system utilized spatially dense data from a scanning set-up, non-linear reconstruction, and micro-CT anatomical information. Weekly measurements were performed. Blood flow changes in autografts, which heal successfully, were localized to graft regions and consistent across mice. Poor healing allografts showed heterogeneous blood flow elevation and high inter-subject variabilities. Allografts with tissue-engineered periosteum showed responses intermediate to both autografts and allografts, consistent with healing observed. These findings suggest that spatiotemporal blood flow changes can be utilized to differentiate the degree of bone graft healing.

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References

Jacques S . Optical properties of biological tissues: a review. Phys Med Biol. 2013; 58(11):R37-61. DOI: 10.1088/0031-9155/58/11/R37. View

Durduran T, Choe R, Baker W, Yodh A . Diffuse Optics for Tissue Monitoring and Tomography. Rep Prog Phys. 2015; 73(7). PMC: 4482362. DOI: 10.1088/0034-4885/73/7/076701. View

Han S, Hoffman M, Proctor A, Vella J, Mannoh E, Barber N . Non-Invasive Monitoring of Temporal and Spatial Blood Flow during Bone Graft Healing Using Diffuse Correlation Spectroscopy. PLoS One. 2015; 10(12):e0143891. PMC: 4666601. DOI: 10.1371/journal.pone.0143891. View

Yalavarthy P, Pogue B, Dehghani H, Paulsen K . Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography. Med Phys. 2007; 34(6):2085-98. DOI: 10.1118/1.2733803. View

Tomlinson R, Silva M . Skeletal Blood Flow in Bone Repair and Maintenance. Bone Res. 2015; 1(4):311-22. PMC: 4472118. DOI: 10.4248/BR201304002. View

Mankin H, Hornicek F, Raskin K . Infection in massive bone allografts. Clin Orthop Relat Res. 2005; (432):210-6. DOI: 10.1097/01.blo.0000150371.77314.52. View

Johansson J, Mireles M, Morales-Dalmau J, Farzam P, Martinez-Lozano M, Casanovas O . Scanning, non-contact, hybrid broadband diffuse optical spectroscopy and diffuse correlation spectroscopy system. Biomed Opt Express. 2016; 7(2):481-98. PMC: 4771466. DOI: 10.1364/BOE.7.000481. View

Binzoni T, Sanguinetti B, Van De Ville D, Zbinden H, Martelli F . Probability density function of the electric field in diffuse correlation spectroscopy of human bone in vivo. Appl Opt. 2016; 55(4):757-62. DOI: 10.1364/AO.55.000757. View

Roche-Labarbe N, Carp S, Surova A, Patel M, Boas D, Grant P . Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life. Hum Brain Mapp. 2009; 31(3):341-52. PMC: 2826558. DOI: 10.1002/hbm.20868. View

10.

Hoffman M, Xie C, Zhang X, Benoit D . The effect of mesenchymal stem cells delivered via hydrogel-based tissue engineered periosteum on bone allograft healing. Biomaterials. 2013; 34(35):8887-98. PMC: 3794711. DOI: 10.1016/j.biomaterials.2013.08.005. View

11.

Kalfas I . Principles of bone healing. Neurosurg Focus. 2006; 10(4):E1. DOI: 10.3171/foc.2001.10.4.2. View

12.

Hoffman M, Van Hove A, Benoit D . Degradable hydrogels for spatiotemporal control of mesenchymal stem cells localized at decellularized bone allografts. Acta Biomater. 2014; 10(8):3431-41. PMC: 4085794. DOI: 10.1016/j.actbio.2014.04.012. View

13.

Yu G, Floyd T, Durduran T, Zhou C, Wang J, Detre J . Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI. Opt Express. 2009; 15(3):1064-75. DOI: 10.1364/oe.15.001064. View

14.

Yu G, Durduran T, Lech G, Zhou C, Chance B, Mohler 3rd E . Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies. J Biomed Opt. 2005; 10(2):024027. DOI: 10.1117/1.1884603. View

15.

Zhou C, Eucker S, Durduran T, Yu G, Ralston J, Friess S . Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury. J Biomed Opt. 2009; 14(3):034015. PMC: 3169814. DOI: 10.1117/1.3146814. View

16.

Koo H, Hupel T, Zdero R, Tov A, Schemitsch E . The effect of muscle contusion on cortical bone and muscle perfusion following reamed, intramedullary nailing: a novel canine tibia fracture model. J Orthop Surg Res. 2010; 5:89. PMC: 3012660. DOI: 10.1186/1749-799X-5-89. View

17.

Haskell R, Svaasand L, Tsay T, Feng T, McAdams M, Tromberg B . Boundary conditions for the diffusion equation in radiative transfer. J Opt Soc Am A Opt Image Sci Vis. 1994; 11(10):2727-41. DOI: 10.1364/josaa.11.002727. View

18.

Mesquita R, Skuli N, Kim M, Liang J, Schenkel S, Majmundar A . Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia. Biomed Opt Express. 2011; 1(4):1173-1187. PMC: 3018079. DOI: 10.1364/BOE.1.001173. View

19.

Buckley E, Cook N, Durduran T, Kim M, Zhou C, Choe R . Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound. Opt Express. 2009; 17(15):12571-81. PMC: 2723781. DOI: 10.1364/oe.17.012571. View

20.

Chang H, Knothe Tate M . Concise review: the periosteum: tapping into a reservoir of clinically useful progenitor cells. Stem Cells Transl Med. 2012; 1(6):480-91. PMC: 3659712. DOI: 10.5966/sctm.2011-0056. View