Validation of Diffuse Correlation Spectroscopy for Muscle Blood Flow with Concurrent Arterial Spin Labeled Perfusion MRI

Overview

Journal Opt Express

Specialties Biophysics
Ophthalmology

Date 2009 Jun 18

PMID 19532334

Citations 120

Authors

Guoqiang Yu

Thomas F Floyd

Turgut Durduran

Chao Zhou

Jiongjiong Wang

John A Detre

Arjun G Yodh

Affiliations

Soon will be listed here.

Abstract

Calf blood flow was measured simultaneously in healthy human subjects (n = 7) during cuff inflation and deflation using near-infrared diffuse correlation spectroscopy (DCS) and arterial spin labeled perfusion MRI (ASL-MRI). The DCS and ASL-MRI data exhibited highly correlated absolute and relative dynamic flow responses in each individual (p < 0.001). Peak flow variations during hyperemia were also significantly correlated, though more for relative (p = 0.003) than absolute (p = 0.016) flow. Repeated measurement variation was less than 8% for both modalities. The results provide much needed quantitative blood flow validation of the diffuse optical correlation method in humans.

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