Associations of Dietary Intakes of Anthocyanins and Berry Fruits with Risk of Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis of Prospective Cohort Studies

Overview

Journal Eur J Clin Nutr

Specialty Nutritional Sciences

Date 2016 Aug 18

PMID 27530472

Citations 54

Authors

X Guo

B Yang

J Tan

J Jiang

D Li

Affiliations

Soon will be listed here.

Abstract

To investigate the associations of dietary intakes of anthocyanins and berry fruits with type 2 diabetes mellitus (T2DM) risk and to evaluate the potential dose-response relationships based on prospective cohort studies. Cochrane library, Embase and PubMed databases were systematically searched up to Jan 2016 for relevant original studies. Summary relative risks (RRs) were calculated with a random effects model comparing the highest with lowest category. Dose-response was estimated using restricted cubic spline regression models. Three cohort studies reporting dietary anthocyanin intake with 200 894 participants and 12 611 T2DM incident cases, and five cohort studies reporting berry intake with 194 019 participants and 13 013 T2DM incident cases were investigated. Dietary anthocyanin consumption was associated with a 15% reduction of T2DM risk (summary RR=0.85; 95% confidence interval (CI): 0.80-0.91; I=14.5%). Consumption of berries was associated with an 18% reduction of T2DM risk (summary RR=0.82, 95% CI: 0.76-0.89; I=48.6%). Significant curvilinear associations were found between dietary intake of anthocyanins (P for nonlinearity=0.006) and berries (P for nonlinearity=0.028) and T2DM risk, respectively. The risk of T2DM was decreased by 5%, with a 7.5 mg/day increment of dietary anthocyanin intake (RR=0.95; 95% CI: 0.93-0.98; I=0.00%) or with a 17 g/day increment of berry intake (RR=0.95, 95% CI: 0.91-0.99; I=0.00%), respectively. Higher dietary intakes of anthocyanins and berry fruits are associated with a lower T2DM risk.

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References

Montonen J, Knekt P, Jarvinen R, Aromaa A, Reunanen A . Whole-grain and fiber intake and the incidence of type 2 diabetes. Am J Clin Nutr. 2003; 77(3):622-9. DOI: 10.1093/ajcn/77.3.622. View

Jackson D, White I, Thompson S . Extending DerSimonian and Laird's methodology to perform multivariate random effects meta-analyses. Stat Med. 2009; 29(12):1282-97. DOI: 10.1002/sim.3602. View

Baker R, Hayden M, Ghosh S . NF-κB, inflammation, and metabolic disease. Cell Metab. 2011; 13(1):11-22. PMC: 3040418. DOI: 10.1016/j.cmet.2010.12.008. View

Wei X, Wang D, Yang Y, Xia M, Li D, Li G . Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity. J Sci Food Agric. 2011; 91(6):1006-13. DOI: 10.1002/jsfa.4275. View

Calder P . Mechanisms of action of (n-3) fatty acids. J Nutr. 2012; 142(3):592S-599S. DOI: 10.3945/jn.111.155259. View

Kurimoto Y, Shibayama Y, Inoue S, Soga M, Takikawa M, Ito C . Black soybean seed coat extract ameliorates hyperglycemia and insulin sensitivity via the activation of AMP-activated protein kinase in diabetic mice. J Agric Food Chem. 2013; 61(23):5558-64. DOI: 10.1021/jf401190y. View

Jacques P, Cassidy A, Rogers G, Peterson J, Meigs J, Dwyer J . Higher dietary flavonol intake is associated with lower incidence of type 2 diabetes. J Nutr. 2013; 143(9):1474-80. PMC: 3743276. DOI: 10.3945/jn.113.177212. View

Montonen J, Jarvinen R, Heliovaara M, Reunanen A, Aromaa A, Knekt P . Food consumption and the incidence of type II diabetes mellitus. Eur J Clin Nutr. 2005; 59(3):441-8. DOI: 10.1038/sj.ejcn.1602094. View

Jennings A, Welch A, Spector T, MacGregor A, Cassidy A . Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. J Nutr. 2013; 144(2):202-8. DOI: 10.3945/jn.113.184358. View

10.

Mursu J, Virtanen J, Tuomainen T, Nurmi T, Voutilainen S . Intake of fruit, berries, and vegetables and risk of type 2 diabetes in Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2013; 99(2):328-33. DOI: 10.3945/ajcn.113.069641. View

11.

Nizamutdinova I, Jin Y, Chung J, Shin S, Lee S, Seo H . The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis. Mol Nutr Food Res. 2009; 53(11):1419-29. DOI: 10.1002/mnfr.200800526. View

12.

Guo H, Ling W . The update of anthocyanins on obesity and type 2 diabetes: experimental evidence and clinical perspectives. Rev Endocr Metab Disord. 2015; 16(1):1-13. DOI: 10.1007/s11154-014-9302-z. View

13.

Orsini N, Li R, Wolk A, Khudyakov P, Spiegelman D . Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software. Am J Epidemiol. 2011; 175(1):66-73. PMC: 3244608. DOI: 10.1093/aje/kwr265. View

14.

Wallace T . Anthocyanins in cardiovascular disease. Adv Nutr. 2012; 2(1):1-7. PMC: 3042791. DOI: 10.3945/an.110.000042. View

15.

Chiang A, Wu H, Yeh H, Chu C, Lin H, Lee W . Antioxidant effects of black rice extract through the induction of superoxide dismutase and catalase activities. Lipids. 2006; 41(8):797-803. DOI: 10.1007/s11745-006-5033-6. View

16.

DerSimonian R, Laird N . Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177-88. DOI: 10.1016/0197-2456(86)90046-2. View

17.

Yang B, Wang F, Ren X, Li D . Biospecimen long-chain N-3 PUFA and risk of colorectal cancer: a meta-analysis of data from 60,627 individuals. PLoS One. 2014; 9(11):e110574. PMC: 4222788. DOI: 10.1371/journal.pone.0110574. View

18.

Stull A, Cash K, Johnson W, Champagne C, Cefalu W . Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women. J Nutr. 2010; 140(10):1764-8. PMC: 3139238. DOI: 10.3945/jn.110.125336. View

19.

Daar A, Singer P, Persad D, Pramming S, Matthews D, Beaglehole R . Grand challenges in chronic non-communicable diseases. Nature. 2007; 450(7169):494-6. DOI: 10.1038/450494a. View

20.

Wang L, Stoner G . Anthocyanins and their role in cancer prevention. Cancer Lett. 2008; 269(2):281-90. PMC: 2582525. DOI: 10.1016/j.canlet.2008.05.020. View