Cyanidin-3-O-glucoside As a Nutrigenomic Factor in Type 2 Diabetes and Its Prominent Impact on Health

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jun 10

PMID 37298715

Authors

Iga Bartel

Magdalena Koszarska

Nina Strzalkowska

Nikolay T Tzvetkov

Dongdong Wang

Jaroslaw O Horbanczuk

Agnieszka Wierzbicka

Atanas G Atanasov

Artur Jozwik

Affiliations

Soon will be listed here.

Abstract

Type 2 diabetes (T2D) accounts for a global health problem. It is a complex disease as a result of the combination of environmental as well as genetic factors. Morbidity is still increasing across the world. One of the possibilities for the prevention and mitigation of the negative consequences of type 2 diabetes is a nutritional diet rich in bioactive compounds such as polyphenols. This review is focused on cyanidin-3-O-glucosidase (C3G), which belongs to the anthocyanins subclass, and its anti-diabetic properties. There are numerous pieces of evidence that C3G exerts positive effects on diabetic parameters, including in vitro and in vivo studies. It is involved in alleviating inflammation, reducing blood glucose, controlling postprandial hyperglycemia, and gene expression related to the development of T2D. C3G is one of the beneficial polyphenolic compounds that may help to overcome the public health problems associated with T2D.

Citing Articles

Anthocyanins and Type 2 Diabetes: An Update of Human Study and Clinical Trial.

Kozlowska A, Nitsch-Osuch A Nutrients. 2024; 16(11).

PMID: 38892607 PMC: 11174612. DOI: 10.3390/nu16111674.

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