Anthocyanins and Their Role in Cancer Prevention

Overview

Journal Cancer Lett

Specialty Oncology

Date 2008 Jun 24

PMID 18571839

Citations 222

Authors

Li-Shu Wang

Gary D Stoner

Affiliations

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Abstract

Anthocyanins are the most abundant flavonoid constituents of fruits and vegetables. The conjugated bonds in their structures, which absorb light at about 500 nm, are the basis for the bright red, blue and purple colors of fruits and vegetables, as well as the autumn foliage of deciduous trees. The daily intake of anthocyanins in residents of the United States is estimated to be about 200 mg or about 9-fold higher than that of other dietary flavonoids. In this review, we summarize the latest developments on the anti-carcinogenic activities of anthocyanins and anthocyanin-rich extracts in cell culture models and in animal model tumor systems, and discuss their molecular mechanisms of action. We also suggest reasons for the apparent lack of correlation between the effectiveness of anthocyanins in laboratory model systems and in humans as evidenced by epidemiological studies. Future studies aimed at enhancing the absorption of anthocyanins and/or their metabolites are likely to be necessary for their ultimate use for chemoprevention of human cancer.

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References

Seeram N, Adams L, Zhang Y, Lee R, Sand D, Scheuller H . Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem. 2006; 54(25):9329-39. DOI: 10.1021/jf061750g. View

Shih P, Yeh C, Yen G . Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis. J Agric Food Chem. 2007; 55(23):9427-35. DOI: 10.1021/jf071933i. View

Zhang Y, Vareed S, Nair M . Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. Life Sci. 2005; 76(13):1465-72. DOI: 10.1016/j.lfs.2004.08.025. View

Rodrigo K, Rawal Y, Renner R, Schwartz S, Tian Q, Larsen P . Suppression of the tumorigenic phenotype in human oral squamous cell carcinoma cells by an ethanol extract derived from freeze-dried black raspberries. Nutr Cancer. 2006; 54(1):58-68. PMC: 2392889. DOI: 10.1207/s15327914nc5401_7. View

Chen P, Chu S, Chiou H, Chiang C, Yang S, Hsieh Y . Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo. Nutr Cancer. 2006; 53(2):232-43. DOI: 10.1207/s15327914nc5302_12. View

Reddivari L, Vanamala J, Chintharlapalli S, Safe S, Miller Jr J . Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways. Carcinogenesis. 2007; 28(10):2227-35. DOI: 10.1093/carcin/bgm117. View

Coates E, Popa G, Gill C, McCann M, McDougall G, Stewart D . Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer. J Carcinog. 2007; 6:4. PMC: 1868020. DOI: 10.1186/1477-3163-6-4. View

Prior R, Wu X . Anthocyanins: structural characteristics that result in unique metabolic patterns and biological activities. Free Radic Res. 2006; 40(10):1014-28. DOI: 10.1080/10715760600758522. View

He J, Magnuson B, Lala G, Tian Q, Schwartz S, Giusti M . Intact anthocyanins and metabolites in rat urine and plasma after 3 months of anthocyanin supplementation. Nutr Cancer. 2006; 54(1):3-12. DOI: 10.1207/s15327914nc5401_2. View

10.

Bode U, Hasan C, Hulsmann B, Fleischhack G . Recancostat compositum therapy does not prevent tumor progression in young cancer patients. Klin Padiatr. 1999; 211(4):353-5. DOI: 10.1055/s-2008-1043813. View

11.

Renis M, Calandra L, Scifo C, Tomasello B, Cardile V, Vanella L . Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins. Br J Nutr. 2007; 100(1):27-35. DOI: 10.1017/S0007114507876239. View

12.

Bobe G, Wang B, Seeram N, Nair M, Bourquin L . Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindac. J Agric Food Chem. 2006; 54(25):9322-8. DOI: 10.1021/jf0612169. View

13.

Martin S, Giannone G, Andriantsitohaina R, Martinez M . Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis. Br J Pharmacol. 2003; 139(6):1095-102. PMC: 1573941. DOI: 10.1038/sj.bjp.0705347. View

14.

Hakimuddin F, Paliyath G, Meckling K . Selective cytotoxicity of a red grape wine flavonoid fraction against MCF-7 cells. Breast Cancer Res Treat. 2004; 85(1):65-79. DOI: 10.1023/B:BREA.0000021048.52430.c0. View

15.

Olsson M, Gustavsson K, Andersson S, Nilsson A, Duan R . Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J Agric Food Chem. 2004; 52(24):7264-71. DOI: 10.1021/jf030479p. View

16.

Stoner G, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V . Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. J Clin Pharmacol. 2005; 45(10):1153-64. DOI: 10.1177/0091270005279636. View

17.

Favot L, Martin S, Keravis T, Andriantsitohaina R, Lugnier C . Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis. Cardiovasc Res. 2003; 59(2):479-87. DOI: 10.1016/s0008-6363(03)00433-4. View

18.

Hou D, Kai K, Li J, Lin S, Terahara N, Wakamatsu M . Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms. Carcinogenesis. 2003; 25(1):29-36. DOI: 10.1093/carcin/bgg184. View

19.

Zhang Y, Seeram N, Lee R, Feng L, Heber D . Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties. J Agric Food Chem. 2008; 56(3):670-5. DOI: 10.1021/jf071989c. View

20.

Galvano F, La Fauci L, Lazzarino G, Fogliano V, Ritieni A, Ciappellano S . Cyanidins: metabolism and biological properties. J Nutr Biochem. 2004; 15(1):2-11. DOI: 10.1016/j.jnutbio.2003.07.004. View