Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2016 Jul 20

PMID 27430722

Citations 104

Authors

Burton E Barnett

Ryan P Staupe

Pamela M Odorizzi

Olesya Palko

Vesselin T Tomov

Alison E Mahan

Bronwyn Gunn

Diana Chen

Michael A Paley

Galit Alter

Steven L Reiner

Georg M Lauer

John R Teijaro

E John Wherry

Affiliations

Soon will be listed here.

Abstract

The role of Ab and B cells in preventing infection is established. In contrast, the role of B cell responses in containing chronic infections remains poorly understood. IgG2a (IgG1 in humans) can prevent acute infections, and T-bet promotes IgG2a isotype switching. However, whether IgG2a and B cell-expressed T-bet influence the host-pathogen balance during persisting infections is unclear. We demonstrate that B cell-specific loss of T-bet prevents control of persisting viral infection. T-bet in B cells controlled IgG2a production, as well as mucosal localization, proliferation, glycosylation, and a broad transcriptional program. T-bet controlled a broad antiviral program in addition to IgG2a because T-bet in B cells was important, even in the presence of virus-specific IgG2a. Our data support a model in which T-bet is a universal controller of antiviral immunity across multiple immune lineages.

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