T-bet: a Bridge Between Innate and Adaptive Immunity

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2013 Oct 12

PMID 24113868

Citations 264

Authors

Vanja Lazarevic

Laurie H Glimcher

Graham M Lord

Affiliations

Soon will be listed here.

Abstract

Originally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T-bet is now recognized as having an important role in many cells of the adaptive and innate immune system. T-bet has a fundamental role in coordinating type 1 immune responses by controlling a network of genetic programmes that regulate the development of certain immune cells and the effector functions of others. Many of these transcriptional networks are conserved across innate and adaptive immune cells and these shared mechanisms highlight the biological functions that are regulated by T-bet.

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