Pleiotropic Genes Affecting Carcass Traits in Bos Indicus (Nellore) Cattle Are Modulators of Growth

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2016 Jul 14

PMID 27410030

Citations 12

Authors

Anirene G T Pereira

Yuri T Utsunomiya

Marco Milanesi

Rafaela B P Torrecilha

Adriana S Carmo

Haroldo H R Neves

Roberto Carvalheiro

Paolo Ajmone-Marsan

Tad S Sonstegard

Johann Solkner

Carmen J Contreras-Castillo

Jose F Garcia

Affiliations

Soon will be listed here.

Abstract

Two complementary methods, namely Multi-Trait Meta-Analysis and Versatile Gene-Based Test for Genome-wide Association Studies (VEGAS), were used to identify putative pleiotropic genes affecting carcass traits in Bos indicus (Nellore) cattle. The genotypic data comprised over 777,000 single-nucleotide polymorphism markers scored in 995 bulls, and the phenotypic data included deregressed breeding values (dEBV) for weight measurements at birth, weaning and yearling, as well visual scores taken at weaning and yearling for carcass finishing precocity, conformation and muscling. Both analyses pointed to the pleomorphic adenoma gene 1 (PLAG1) as a major pleiotropic gene. VEGAS analysis revealed 224 additional candidates. From these, 57 participated, together with PLAG1, in a network involved in the modulation of the function and expression of IGF1 (insulin like growth factor 1), IGF2 (insulin like growth factor 2), GH1 (growth hormone 1), IGF1R (insulin like growth factor 1 receptor) and GHR (growth hormone receptor), suggesting that those pleiotropic genes operate as satellite regulators of the growth pathway.

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