MiRNAs Signature in Head and Neck Squamous Cell Carcinoma Metastasis: A Literature Review

Overview

Journal J Dent (Shiraz)

Publisher Shiraz University of Medical Sciences

Date 2016 Jun 11

PMID 27284551

Citations 31

Authors

Soussan Irani

Affiliations

Soon will be listed here.

Abstract

Statement Of The Problem: Head and neck cancers include epithelial tumors arising in the oral cavity, pharynx, larynx, paranasal sinuses, and nasal cavity. Metastasis is a hallmark of cancer. MicroRNAs (miRNAs) are endogenous small non-coding RNAs involved in cell proliferation, development, differentiation and metastasis. It is believed that miRNA alterations correlate with initiation and progression of cancer cell proliferation or inhibition of tumorigenesis. Moreover, miRNAs have different roles in development, progression, and metastasis of head and neck squamous cell carcinoma (HNSCC). Altered expression of miRNAs could be novel molecular biomarkers for the definite diagnosis of cancer, metastatic site, cancer stage, and its progression.

Purpose: The purpose of this review was to provide a comprehensive literature review of the role of miRNAs in head and neck cancer metastasis.

Search Strategy: A relevant English literature search in PubMed, ScienceDirect, and Google Scholar was performed. The keywords 'miRNA', 'head and neck', and 'cancer' were searched in title and abstract of publications; limited from 1990 to 2015. The inclusion criterion was the role of miRNAs in cancer metastasis. The exclusion criterion was the other functions of miRNAs in cancers. Out of 15221 articles, the full texts of 442 articles were retrieved and only 133 articles met the inclusion criteria.

Conclusion: Despite the advances in cancer treatment, the mortality rate of HNSCC is still high. The potential application of miRNAs for cancer therapy has been demonstrated in many studies; miRNAs function as either tumor suppressor or oncogene. The recognition of metastamir and their targets may lead to better understanding of HNSCC oncogenesis, and consequently, development of new therapeutic strategies which is a necessity in cancer treatment. Development of therapeutic agents based on miRNAs is a promising target.

Citing Articles

Differential Immunomodulatory Effects of Head and Neck Cancer-Derived Exosomes on B Cells in the Presence of ATP.

Coray M, Goldi V, Schmid L, Benecke L, Figueiro F, Muller L Int J Mol Sci. 2022; 23(22).

PMID: 36430925 PMC: 9693630. DOI: 10.3390/ijms232214446.

Promising Biomarkers in Head and Neck Cancer: The Most Clinically Important miRNAs.

Thomaidou A, Batsaki P, Adamaki M, Goulielmaki M, Baxevanis C, Zoumpourlis V Int J Mol Sci. 2022; 23(15).

PMID: 35897831 PMC: 9367895. DOI: 10.3390/ijms23158257.

MicroRNAs in head and neck squamous cell carcinoma: a possible challenge as biomarkers, determinants for the choice of therapy and targets for personalized molecular therapies.

Vahabi M, Blandino G, Di Agostino S Transl Cancer Res. 2022; 10(6):3090-3110.

PMID: 35116619 PMC: 8797920. DOI: 10.21037/tcr-20-2530.

Influences HNSCC Development and Progression through Regulation of the Epithelial-to-Mesenchymal Transition Process and Could Be Used as a Potential Biomarker.

Tomaszewska W, Kozlowska-Maslon J, Baranowski D, Perkowska A, Szalkowska S, Kazimierczak U Biomedicines. 2021; 9(12).

PMID: 34944712 PMC: 8698850. DOI: 10.3390/biomedicines9121894.

Long Intergenic Non-Coding RNAs in HNSCC: From "Junk DNA" to Important Prognostic Factor.

Kozlowska J, Kolenda T, Poter P, Sobocinska J, Guglas K, Stasiak M Cancers (Basel). 2021; 13(12).

PMID: 34204634 PMC: 8231241. DOI: 10.3390/cancers13122949.

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