MicroRNA Control of Epithelial-mesenchymal Transition and Metastasis

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 2012 Jun 12

PMID 22684369

Citations 151

Authors

Jinsong Zhang

Li Ma

Affiliations

Soon will be listed here.

Abstract

The great majority of cancer deaths are due to metastasis, which remains a poorly understood pathological process. The formation of a metastasis reflects a succession of complex steps leading to the macroscopic outgrowth of disseminated tumor cells at the secondary site. In the past 5 years, certain microRNAs (miRNAs) have been shown to regulate either a single step or multiple steps of metastasis, doing so by downregulating the expression of their target genes. In this review, we discuss recent studies on the functions and molecular mechanisms of miRNAs in regulating epithelial-mesenchymal transition (EMT) and cancer metastasis.

Citing Articles

Exploring the therapeutic potential of natural products in modulating miRNA networks in prostate cancer.

Mohammed O Naunyn Schmiedebergs Arch Pharmacol. 2025; .

PMID: 39976718 DOI: 10.1007/s00210-025-03898-2.

Epithelial-mesenchymal transition in asthma: its role and underlying regulatory mechanisms.

Zhang B, Feng X, Tian L, Xiao B, Hou L, Mo B Front Immunol. 2025; 16:1519998.

PMID: 39911398 PMC: 11794105. DOI: 10.3389/fimmu.2025.1519998.

Modeling ncRNA-Mediated Circuits in Cell Fate Decision: From Systems Biology to Synthetic Biology.

Tian X, Zhang R, Ferro M, Goetz H Methods Mol Biol. 2024; 2883:139-154.

PMID: 39702707 DOI: 10.1007/978-1-0716-4290-0_6.

A new perspective on diagnostic strategies concerning the potential of saliva-based miRNA signatures in oral cancer.

Prasad M, Sekar R, Priya M, Varma S, Karobari M Diagn Pathol. 2024; 19(1):147.

PMID: 39548527 PMC: 11568613. DOI: 10.1186/s13000-024-01575-1.

MR Molecular Image Guided Treatment of Pancreatic Cancer with Targeted ECO/miR-200c Nanoparticles in Immunocompetent Mouse Tumor Models.

Laney V, Hall R, Yuan X, Hampson E, Halle A, Yeung G Pharm Res. 2024; 41(9):1811-1825.

PMID: 39198318 PMC: 11436418. DOI: 10.1007/s11095-024-03762-7.

References

Mayr C, Hemann M, Bartel D . Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science. 2007; 315(5818):1576-9. PMC: 2556962. DOI: 10.1126/science.1137999. View

Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo Y . MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res. 2008; 18(3):350-9. DOI: 10.1038/cr.2008.24. View

Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S . A MicroRNA targeting dicer for metastasis control. Cell. 2010; 141(7):1195-207. DOI: 10.1016/j.cell.2010.05.017. View

Korpal M, Ell B, Buffa F, Ibrahim T, Blanco M, Celia-Terrassa T . Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med. 2011; 17(9):1101-8. PMC: 3169707. DOI: 10.1038/nm.2401. View

Song G, Zhang Y, Wang L . MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation. J Biol Chem. 2009; 284(46):31921-7. PMC: 2797263. DOI: 10.1074/jbc.M109.046862. View

Tay Y, Kats L, Salmena L, Weiss D, Tan S, Ala U . Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell. 2011; 147(2):344-57. PMC: 3235920. DOI: 10.1016/j.cell.2011.09.029. View

Ma L, Teruya-Feldstein J, Weinberg R . Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 2007; 449(7163):682-8. DOI: 10.1038/nature06174. View

Meng Z, Fu X, Chen X, Zeng S, Tian Y, Jove R . miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice. Hepatology. 2010; 52(6):2148-57. PMC: 3076553. DOI: 10.1002/hep.23915. View

Nakata K, Ohuchida K, Mizumoto K, Kayashima T, Ikenaga N, Sakai H . MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis. Surgery. 2011; 150(5):916-22. DOI: 10.1016/j.surg.2011.06.017. View

10.

Tsai W, Hsu P, Lai T, Chau G, Lin C, Chen C . MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. Hepatology. 2009; 49(5):1571-82. DOI: 10.1002/hep.22806. View

11.

Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M . DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene. 2005; 24(14):2375-85. DOI: 10.1038/sj.onc.1208429. View

12.

Crawford M, Brawner E, Batte K, Yu L, Hunter M, Otterson G . MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem Biophys Res Commun. 2008; 373(4):607-12. DOI: 10.1016/j.bbrc.2008.06.090. View

13.

Camps C, Buffa F, Colella S, Moore J, Sotiriou C, Sheldon H . hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer. Clin Cancer Res. 2008; 14(5):1340-8. DOI: 10.1158/1078-0432.CCR-07-1755. View

14.

Mani S, Guo W, Liao M, Eaton E, Ayyanan A, Zhou A . The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008; 133(4):704-15. PMC: 2728032. DOI: 10.1016/j.cell.2008.03.027. View

15.

Xu D, Takeshita F, Hino Y, Fukunaga S, Kudo Y, Tamaki A . miR-22 represses cancer progression by inducing cellular senescence. J Cell Biol. 2011; 193(2):409-24. PMC: 3080260. DOI: 10.1083/jcb.201010100. View

16.

Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko Jr R . microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res. 2009; 69(20):8157-65. PMC: 2763324. DOI: 10.1158/0008-5472.CAN-09-1996. View

17.

Voorhoeve P, le Sage C, Schrier M, Gillis A, Stoop H, Nagel R . A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell. 2006; 124(6):1169-81. DOI: 10.1016/j.cell.2006.02.037. View

18.

Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C . let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007; 131(6):1109-23. DOI: 10.1016/j.cell.2007.10.054. View

19.

Chang T, Zeitels L, Hwang H, Chivukula R, Wentzel E, Dews M . Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation. Proc Natl Acad Sci U S A. 2009; 106(9):3384-9. PMC: 2651245. DOI: 10.1073/pnas.0808300106. View

20.

Yang Q, Jie Z, Cao H, Greenlee A, Yang C, Zou F . Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C. Carcinogenesis. 2011; 32(5):713-22. DOI: 10.1093/carcin/bgr035. View