Diagnostic Value of Contrast-enhanced Ultrasound in Papillary Thyroid Microcarcinoma

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2016 May 12

PMID 27168773

Citations 18

Authors

Hong Yan Chen

Wei Yan Liu

Hui Zhu

Dao Wen Jiang

Dong Hua Wang

Yongqi Chen

Weihua Li

Gaofeng Pan

Affiliations

Soon will be listed here.

Abstract

The aim of the present study was to explore the value and characteristics of contrast-enhanced ultrasound (CEUS) in the diagnosis of papillary thyroid microcarcinoma (PTMC). By analyzing CEUS information of 130 nodules obtained from 106 patients with PTMC, who had been diagnosed by surgery and pathological analysis, CEUS characteristics of PTMC nodules were concluded. Based on the results, the PTMC nodules were divided into three groups as follows: 32 nodules (24.62%) were found to be enhanced earlier than the surrounding normal thyroid tissue, 95 nodules (73.08%) were enhanced at the same time as the normal thyroid tissue and 3 nodules (2.30%) were enhanced later than the normal thyroid tissue. The results also demonstrated that the peak enhancement intensity of the 130 nodules was lower compared with the irregular intensity of the normal parenchyma in corresponding thyroids, and that PTMC enhancement washed out faster than in normal thyroid parenchyma. In conclusion, the PTMC characteristics that CEUS can detect may improve the diagnostic accuracy and provide valuable information for the treatment of the disease.

Citing Articles

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References

Friedrich-Rust M, Sperber A, Holzer K, Diener J, Grunwald F, Badenhoop K . Real-time elastography and contrast-enhanced ultrasound for the assessment of thyroid nodules. Exp Clin Endocrinol Diabetes. 2009; 118(9):602-9. DOI: 10.1055/s-0029-1237701. View

Mitchell J, Parangi S . Angiogenesis in benign and malignant thyroid disease. Thyroid. 2005; 15(6):494-510. DOI: 10.1089/thy.2005.15.494. View

Dietrich C, Ignee A, Hocke M, Schreiber-Dietrich D, Greis C . Pitfalls and artefacts using contrast enhanced ultrasound. Z Gastroenterol. 2011; 49(3):350-6. DOI: 10.1055/s-0029-1245851. View

Hughes D, Haymart M, Miller B, Gauger P, Doherty G . The most commonly occurring papillary thyroid cancer in the United States is now a microcarcinoma in a patient older than 45 years. Thyroid. 2011; 21(3):231-6. DOI: 10.1089/thy.2010.0137. View

Cosgrove D . Microbubble enhancement of tumour neovascularity. Eur Radiol. 1999; 9 Suppl 3:S413-4. DOI: 10.1007/pl00014086. View

Molinari F, Mantovani A, Deandrea M, Limone P, Garberoglio R, Suri J . Characterization of single thyroid nodules by contrast-enhanced 3-D ultrasound. Ultrasound Med Biol. 2010; 36(10):1616-25. DOI: 10.1016/j.ultrasmedbio.2010.07.011. View

Agha A, Jung E, Janke M, Hornung M, Georgieva M, Schlitt H . Preoperative diagnosis of thyroid adenomas using high resolution contrast-enhanced ultrasound (CEUS). Clin Hemorheol Microcirc. 2013; 55(4):403-9. DOI: 10.3233/CH-131777. View

Ito Y, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K . Papillary microcarcinoma of the thyroid: how should it be treated?. World J Surg. 2004; 28(11):1115-21. DOI: 10.1007/s00268-004-7644-5. View

Hornung M, Jung E, Georgieva M, Schlitt H, Stroszczynski C, Agha A . Detection of microvascularization of thyroid carcinomas using linear high resolution contrast-enhanced ultrasonography (CEUS). Clin Hemorheol Microcirc. 2012; 52(2-4):197-203. DOI: 10.3233/CH-2012-1597. View

10.

Giusti M, Orlandi D, Melle G, Massa B, Silvestri E, Minuto F . Is there a real diagnostic impact of elastosonography and contrast-enhanced ultrasonography in the management of thyroid nodules?. J Zhejiang Univ Sci B. 2013; 14(3):195-206. PMC: 3596570. DOI: 10.1631/jzus.B1200106. View

11.

Agha A, Hornung M, Rennert J, Uller W, Lighvani H, Schlitt H . Contrast-enhanced ultrasonography for localization of pathologic glands in patients with primary hyperparathyroidism. Surgery. 2011; 151(4):580-6. DOI: 10.1016/j.surg.2011.08.010. View

12.

Smith-Bindman R, Lebda P, Feldstein V, Sellami D, Goldstein R, Brasic N . Risk of thyroid cancer based on thyroid ultrasound imaging characteristics: results of a population-based study. JAMA Intern Med. 2013; 173(19):1788-96. PMC: 3936789. DOI: 10.1001/jamainternmed.2013.9245. View

13.

Pelizzo M, Boschin I, Toniato A, Piotto A, Bernante P, Pagetta C . Papillary thyroid microcarcinoma (PTMC): prognostic factors, management and outcome in 403 patients. Eur J Surg Oncol. 2006; 32(10):1144-8. DOI: 10.1016/j.ejso.2006.07.001. View

14.

Pelizzo M, Merante Boschin I, Toniato A, Pagetta C, Piotto A, Bernante P . Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience. Nucl Med Commun. 2004; 25(6):547-52. DOI: 10.1097/01.mnm.0000126625.17166.36. View

15.

Roti E, Degli Uberti E, Bondanelli M, Braverman L . Thyroid papillary microcarcinoma: a descriptive and meta-analysis study. Eur J Endocrinol. 2008; 159(6):659-73. DOI: 10.1530/EJE-07-0896. View

16.

Nemec U, Nemec S, Novotny C, Weber M, Czerny C, Krestan C . Quantitative evaluation of contrast-enhanced ultrasound after intravenous administration of a microbubble contrast agent for differentiation of benign and malignant thyroid nodules: assessment of diagnostic accuracy. Eur Radiol. 2012; 22(6):1357-65. DOI: 10.1007/s00330-012-2385-6. View

17.

Seo Y, Yoon D, Baek S, Ku Y, Rho Y, Chung E . Detection of neck recurrence in patients with differentiated thyroid cancer: comparison of ultrasound, contrast-enhanced CT and (18)F-FDG PET/CT using surgical pathology as a reference standard: (ultrasound vs. CT vs. (18)F-FDG PET/CT in.... Eur Radiol. 2012; 22(10):2246-54. DOI: 10.1007/s00330-012-2470-x. View

18.

Rajendra Acharya U, Sree S, Krishnan M, Molinari F, Garberoglio R, Suri J . Non-invasive automated 3D thyroid lesion classification in ultrasound: a class of ThyroScan™ systems. Ultrasonics. 2011; 52(4):508-20. DOI: 10.1016/j.ultras.2011.11.003. View

19.

Deng J, Zhou P, Tian S, Zhang L, Li J, Qian Y . Comparison of diagnostic efficacy of contrast-enhanced ultrasound, acoustic radiation force impulse imaging, and their combined use in differentiating focal solid thyroid nodules. PLoS One. 2014; 9(3):e90674. PMC: 3940946. DOI: 10.1371/journal.pone.0090674. View

20.

Colonna M, Uhry Z, Guizard A, Delafosse P, Schvartz C, Belot A . Recent trends in incidence, geographical distribution, and survival of papillary thyroid cancer in France. Cancer Epidemiol. 2015; 39(4):511-8. DOI: 10.1016/j.canep.2015.04.015. View