Microfluidic Cell Chips for High-throughput Drug Screening

Overview

Journal Bioanalysis

Specialty Chemistry

Date 2016 Apr 14

PMID 27071838

Citations 25

Authors

Chun-Wei Chi

Ah Rezwanuddin Ahmed

Zeynep Dereli-Korkut

Sihong Wang

Affiliations

Soon will be listed here.

Abstract

The current state of screening methods for drug discovery is still riddled with several inefficiencies. Although some widely used high-throughput screening platforms may enhance the drug screening process, their cost and oversimplification of cell-drug interactions pose a translational difficulty. Microfluidic cell-chips resolve many issues found in conventional HTS technology, providing benefits such as reduced sample quantity and integration of 3D cell culture physically more representative of the physiological/pathological microenvironment. In this review, we introduce the advantages of microfluidic devices in drug screening, and outline the critical factors which influence device design, highlighting recent innovations and advances in the field including a summary of commercialization efforts on microfluidic cell chips. Future perspectives of microfluidic cell devices are also provided based on considerations of present technological limitations and translational barriers.

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