Nutrigenetics and Nutrimiromics of the Circadian System: The Time for Human Health

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2016 Mar 2

PMID 26927084

Citations 6

Authors

Victor Mico

Laura Diez-Ricote

Lidia Daimiel

Affiliations

Soon will be listed here.

Abstract

Even though the rhythmic oscillations of life have long been known, the precise molecular mechanisms of the biological clock are only recently being explored. Circadian rhythms are found in virtually all organisms and affect our lives. Thus, it is not surprising that the correct running of this clock is essential for cellular functions and health. The circadian system is composed of an intricate network of genes interwined in an intrincated transcriptional/translational feedback loop. The precise oscillation of this clock is controlled by the circadian genes that, in turn, regulate the circadian oscillations of many cellular pathways. Consequently, variations in these genes have been associated with human diseases and metabolic disorders. From a nutrigenetics point of view, some of these variations modify the individual response to the diet and interact with nutrients to modulate such response. This circadian feedback loop is also epigenetically modulated. Among the epigenetic mechanisms that control circadian rhythms, microRNAs are the least studied ones. In this paper, we review the variants of circadian-related genes associated to human disease and nutritional response and discuss the current knowledge about circadian microRNAs. Accumulated evidence on the genetics and epigenetics of the circadian system points to important implications of chronotherapy in the clinical practice, not only in terms of pharmacotherapy, but also for dietary interventions. However, interventional studies (especially nutritional trials) that include chronotherapy are scarce. Given the importance of chronobiology in human health such studies are warranted in the near future.

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References

Kinoshita C, Aoyama K, Matsumura N, Kikuchi-Utsumi K, Watabe M, Nakaki T . Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels. Nat Commun. 2014; 5:3823. PMC: 4024755. DOI: 10.1038/ncomms4823. View

Duan H, Li X, Hu H, Li Y, Cai Z, Mei X . Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma. Tumour Biol. 2015; 36(9):6679-89. PMC: 4644213. DOI: 10.1007/s13277-015-3356-8. View

Leung W, He M, Chan A, Law P, Wong N . Wnt/β-Catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion. Cancer Lett. 2015; 362(1):97-105. DOI: 10.1016/j.canlet.2015.03.023. View

Yang M, Lee J, Padgett R, Edery I . Circadian regulation of a limited set of conserved microRNAs in Drosophila. BMC Genomics. 2008; 9:83. PMC: 2263044. DOI: 10.1186/1471-2164-9-83. View

Whittaker R, Loy P, Sisman E, Suyama E, Aza-Blanc P, Ingermanson R . Identification of MicroRNAs that control lipid droplet formation and growth in hepatocytes via high-content screening. J Biomol Screen. 2010; 15(7):798-805. DOI: 10.1177/1087057110374991. View

Ferrell J, Chiang J . Circadian rhythms in liver metabolism and disease. Acta Pharm Sin B. 2015; 5(2):113-22. PMC: 4629216. DOI: 10.1016/j.apsb.2015.01.003. View

Bass J, Takahashi J . Circadian integration of metabolism and energetics. Science. 2010; 330(6009):1349-54. PMC: 3756146. DOI: 10.1126/science.1195027. View

Li P, Sheng C, Huang L, Zhang H, Huang L, Cheng Z . MiR-183/-96/-182 cluster is up-regulated in most breast cancers and increases cell proliferation and migration. Breast Cancer Res. 2014; 16(6):473. PMC: 4303194. DOI: 10.1186/s13058-014-0473-z. View

Shende V, Goldrick M, Ramani S, Earnest D . Expression and rhythmic modulation of circulating microRNAs targeting the clock gene Bmal1 in mice. PLoS One. 2011; 6(7):e22586. PMC: 3142187. DOI: 10.1371/journal.pone.0022586. View

10.

Arble D, Bass J, Laposky A, Vitaterna M, Turek F . Circadian timing of food intake contributes to weight gain. Obesity (Silver Spring). 2009; 17(11):2100-2. PMC: 3499064. DOI: 10.1038/oby.2009.264. View

11.

Brewer M, Lange D, Baler R, Anzulovich A . SREBP-1 as a transcriptional integrator of circadian and nutritional cues in the liver. J Biol Rhythms. 2005; 20(3):195-205. DOI: 10.1177/0748730405275952. View

12.

Corbalan-Tutau D, Madrid J, Nicolas F, Garaulet M . Daily profile in two circadian markers "melatonin and cortisol" and associations with metabolic syndrome components. Physiol Behav. 2012; 123:231-5. DOI: 10.1016/j.physbeh.2012.06.005. View

13.

Nagpal N, Kulshreshtha R . miR-191: an emerging player in disease biology. Front Genet. 2014; 5:99. PMC: 4005961. DOI: 10.3389/fgene.2014.00099. View

14.

Na Y, Sung J, Lee S, Lee Y, Choi Y, Park W . Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm. Exp Mol Med. 2009; 41(9):638-47. PMC: 2753657. DOI: 10.3858/emm.2009.41.9.070. View

15.

Paulose J, Wright J, Patel A, Cassone V . Human Gut Bacteria Are Sensitive to Melatonin and Express Endogenous Circadian Rhythmicity. PLoS One. 2016; 11(1):e0146643. PMC: 4709092. DOI: 10.1371/journal.pone.0146643. View

16.

Corbalan-Tutau M, Madrid J, Garaulet M . Timing and duration of sleep and meals in obese and normal weight women. Association with increase blood pressure. Appetite. 2012; 59(1):9-16. DOI: 10.1016/j.appet.2012.03.015. View

17.

Corbalan-Tutau M, Gomez-Abellan P, Madrid J, Canteras M, Ordovas J, Garaulet M . Toward a chronobiological characterization of obesity and metabolic syndrome in clinical practice. Clin Nutr. 2014; 34(3):477-83. DOI: 10.1016/j.clnu.2014.05.007. View

18.

Husse J, Hintze S, Eichele G, Lehnert H, Oster H . Circadian clock genes Per1 and Per2 regulate the response of metabolism-associated transcripts to sleep disruption. PLoS One. 2013; 7(12):e52983. PMC: 3532432. DOI: 10.1371/journal.pone.0052983. View

19.

Woon P, Kaisaki P, Braganca J, Bihoreau M, Levy J, Farrall M . Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci U S A. 2007; 104(36):14412-7. PMC: 1958818. DOI: 10.1073/pnas.0703247104. View

20.

Zheng C, Dalla Man C, Cobelli C, Groop L, Zhao H, Bale A . A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose (IFG) in youth with obesity. Obesity (Silver Spring). 2015; 23(5):1022-9. PMC: 4414047. DOI: 10.1002/oby.21030. View