Circadian Integration of Metabolism and Energetics

Overview

Journal Science

Specialty Science

Date 2010 Dec 4

PMID 21127246

Citations 890

Authors

Joseph Bass

Joseph S Takahashi

Affiliations

Soon will be listed here.

Abstract

Circadian clocks align behavioral and biochemical processes with the day/night cycle. Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms with changes in cellular environment. Genetic disruption of clock genes in mice perturbs metabolic functions of specific tissues at distinct phases of the sleep/wake cycle. Circadian desynchrony, a characteristic of shift work and sleep disruption in humans, also leads to metabolic pathologies. Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions.

Citing Articles

Dual orexin receptor antagonists as promising therapeutics for Alzheimer's disease.

Ragsdale S, Radovich J, Coiduras I, McCall W, Grant S, Lee C NPJ Biol Timing Sleep. 2025; 2(1):11.

PMID: 40066297 PMC: 11890173. DOI: 10.1038/s44323-025-00025-5.

The mediating role of the TyG index in the relationship between circadian syndrome and cancer among middle-aged and elderly Chinese.

Bai Z, Liang J, Nie Y, Wang S, Chang D BMC Cancer. 2025; 25(1):431.

PMID: 40065285 PMC: 11895363. DOI: 10.1186/s12885-025-13816-7.

Identification of potential susceptibility loci for non-small cell lung cancer through whole genome sequencing in circadian rhythm genes.

Xu X, Xu L, Lang Z, Sun G, Pan J, Li X Sci Rep. 2025; 15(1):7825.

PMID: 40050692 PMC: 11885630. DOI: 10.1038/s41598-025-92083-9.

Crosstalk between O-GlcNAcylation and phosphorylation in metabolism: regulation and mechanism.

Zhao Q, Zhou S, Lou W, Qian H, Xu Z Cell Death Differ. 2025; .

PMID: 40045035 DOI: 10.1038/s41418-025-01473-z.

Immunomodulatory role of the stem cell circadian clock in muscle repair.

Zhu P, Pfrender E, Steffeck A, Reczek C, Zhou Y, Thakkar A Sci Adv. 2025; 11(10):eadq8538.

PMID: 40043110 PMC: 11881903. DOI: 10.1126/sciadv.adq8538.

References

Duez H, Staels B . The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism. Diab Vasc Dis Res. 2008; 5(2):82-8. DOI: 10.3132/dvdr.2008.0014. View

Duez H, van der Veen J, Duhem C, Pourcet B, Touvier T, Fontaine C . Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha. Gastroenterology. 2008; 135(2):689-98. DOI: 10.1053/j.gastro.2008.05.035. View

Kiessling S, Eichele G, Oster H . Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag. J Clin Invest. 2010; 120(7):2600-9. PMC: 2898589. DOI: 10.1172/JCI41192. View

Le Martelot G, Claudel T, Gatfield D, Schaad O, Kornmann B, Lo Sasso G . REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol. 2009; 7(9):e1000181. PMC: 2726950. DOI: 10.1371/journal.pbio.1000181. View

Rutter J, Reick M, McKnight S . Metabolism and the control of circadian rhythms. Annu Rev Biochem. 2002; 71:307-31. DOI: 10.1146/annurev.biochem.71.090501.142857. View

Wu X, Xie H, Yu G, Hebert T, Goh B, Smith S . Expression profile of mRNAs encoding core circadian regulatory proteins in human subcutaneous adipose tissue: correlation with age and body mass index. Int J Obes (Lond). 2009; 33(9):971-7. PMC: 2743775. DOI: 10.1038/ijo.2009.137. View

Stokkan K, Yamazaki S, Tei H, Sakaki Y, Menaker M . Entrainment of the circadian clock in the liver by feeding. Science. 2001; 291(5503):490-3. DOI: 10.1126/science.291.5503.490. View

Taheri S, Zeitzer J, Mignot E . The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu Rev Neurosci. 2002; 25:283-313. DOI: 10.1146/annurev.neuro.25.112701.142826. View

Chawla A, Lazar M . Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation. J Biol Chem. 1993; 268(22):16265-9. View

10.

Kudo T, Tamagawa T, Kawashima M, Mito N, Shibata S . Attenuating effect of clock mutation on triglyceride contents in the ICR mouse liver under a high-fat diet. J Biol Rhythms. 2007; 22(4):312-23. DOI: 10.1177/0748730407302625. View

11.

Takahashi J, Hong H, Ko C, McDearmon E . The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet. 2008; 9(10):764-75. PMC: 3758473. DOI: 10.1038/nrg2430. View

12.

Saper C, Scammell T, Lu J . Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005; 437(7063):1257-63. DOI: 10.1038/nature04284. View

13.

Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F . SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008; 134(2):317-28. DOI: 10.1016/j.cell.2008.06.050. View

14.

Green C, Douris N, Kojima S, Strayer C, Fogerty J, Lourim D . Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity. Proc Natl Acad Sci U S A. 2007; 104(23):9888-93. PMC: 1871564. DOI: 10.1073/pnas.0702448104. View

15.

Balsalobre A, Damiola F, Schibler U . A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell. 1998; 93(6):929-37. DOI: 10.1016/s0092-8674(00)81199-x. View

16.

Preitner N, Damiola F, Lopez-Molina L, Zakany J, Duboule D, Albrecht U . The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell. 2002; 110(2):251-60. DOI: 10.1016/s0092-8674(02)00825-5. View

17.

Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D . The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 2008; 134(2):329-40. PMC: 3526943. DOI: 10.1016/j.cell.2008.07.002. View

18.

Buhr E, Yoo S, Takahashi J . Temperature as a universal resetting cue for mammalian circadian oscillators. Science. 2010; 330(6002):379-85. PMC: 3625727. DOI: 10.1126/science.1195262. View

19.

Tasali E, Leproult R, Ehrmann D, Van Cauter E . Slow-wave sleep and the risk of type 2 diabetes in humans. Proc Natl Acad Sci U S A. 2008; 105(3):1044-9. PMC: 2242689. DOI: 10.1073/pnas.0706446105. View

20.

Roesler W, McFie P, Dauvin C . The liver-enriched transcription factor D-site-binding protein activates the promoter of the phosphoenolpyruvate carboxykinase gene in hepatoma cells. J Biol Chem. 1992; 267(29):21235-43. View