MiR-191: an Emerging Player in Disease Biology

Overview

Journal Front Genet

Date 2014 May 6

PMID 24795757

Citations 87

Authors

Neha Nagpal

Ritu Kulshreshtha

Affiliations

Soon will be listed here.

Abstract

Specific microRNAs have emerged as key players in disease biology by playing crucial role in disease development and progression. This review draws attention to one such microRNA, miR-191 that has been recently reported to be abnormally expressed in several cancers (>20) and various other diseases like diabetes-type 2, Crohn' s, pulmonary hypertension, and Alzheimer' s. It regulates important cellular processes such as cell proliferation, differentiation, apoptosis, and migration by targeting important transcription factors, chromatin remodelers, and cell cycle associated genes. Several studies have demonstrated it to be an excellent biomarker for cancer diagnosis and prognosis leading to two patents already in its kitty. In this first review we summarize the current knowledge of the regulation, functions and targets of miR-191 and discuss its potential as a promising disease biomarker and therapeutic target.

Citing Articles

Circulating exosome-derived miR-191-5p is a novel therapeutic biomarker for radiotherapy in esophageal squamous cell carcinoma patients.

Wang H, Matsumoto Y, Maiyulan A, Toyozumi T, Otsuka R, Sekino N Esophagus. 2025; .

PMID: 40064799 DOI: 10.1007/s10388-025-01116-9.

Gonadal miRNomes and transcriptomes in infected fish reveal sexually dimorphic patterns of the immune response.

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miR-191-5p suppresses PRRSV replication by targeting porcine EGFR to enhance interferon signaling.

Pan Y, Zhang L, Ma W, Ibrahim Y, Zhang W, Wang M Front Microbiol. 2024; 15:1473504.

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Human sperm RNA in male infertility.

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