Functional Elucidation of MiR-494 in the Tumorigenesis of Nasopharyngeal Carcinoma

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2015 Mar 27

PMID 25809707

Citations 19

Authors

Hong-Fang Duan

Xiao-Qing Li

Hong-Yi Hu

Yu-Chi Li

Zhi Cai

Xue-Shuang Mei

Peng Yu

Li-Ping Nie

Wei Zhang

Zhen-Dong Yu

Guo-Hui Nie

Affiliations

Soon will be listed here.

Abstract

Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The proliferation, colony formation, migration, and invasion of NPC-derived cells were suppressed, while the cell apoptosis was promoted, when miR-494 was over-expressed in these cells. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC.

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