Tofla Virus: A Newly Identified Nairovirus of the Crimean-Congo Hemorrhagic Fever Group Isolated from Ticks in Japan

Overview

Journal Sci Rep

Specialty Science

Date 2016 Feb 12

PMID 26863911

Citations 15

Authors

Satoshi Shimada

Kotaro Aoki

Takeshi Nabeshima

Yu Fuxun

Yohei Kurosaki

Kazuya Shiogama

Takanori Onouchi

Miako Sakaguchi

Takeshi Fuchigami

Hokuto Ono

Kodai Nishi

Guillermo Posadas-Herrera

Leo Uchida

Yuki Takamatsu

Jiro Yasuda

Yutaka Tsutsumi

Hiromi Fujita

Kouichi Morita

Daisuke Hayasaka

Affiliations

Soon will be listed here.

Abstract

Ixodid ticks transmit several important viral pathogens. We isolated a new virus (Tofla virus: TFLV) from Heamaphysalis flava and Heamaphysalis formsensis in Japan. The full-genome sequences revealed that TFLV belonged to the genus Nairovirus, family Bunyaviridae. Phylogenetic analyses and neutralization tests suggested that TFLV is closely related to the Hazara virus and that it is classified into the Crimean-Congo hemorrhagic fever group. TFLV caused lethal infection in IFNAR KO mice. The TFLV-infected mice exhibited a gastrointestinal disorder, and positron emission tomography-computed tomography images showed a significant uptake of (18)F-fluorodeoxyglucose in the intestinal tract. TFLV was able to infect and propagate in cultured cells of African green monkey-derived Vero E6 cells and human-derived SK-N-SH, T98-G and HEK-293 cells. Although TFLV infections in humans and animals are currently unknown, our findings may provide clues to understand the potential infectivity and to develop of pre-emptive countermeasures against this new tick-borne Nairovirus.

Citing Articles

Isolation and characterization of Iwanai Valley virus, a new tick-borne nairovirus from Ixodes ovatus ticks in Hokkaido, Japan.

Matsumura R, Kobayashi D, Yamauchi T, Park E, Nishino A, Maeda K Arch Virol. 2024; 170(1):23.

PMID: 39708165 DOI: 10.1007/s00705-024-06195-0.

Establishment of a lethal mouse model of emerging tick-borne orthonairovirus infections.

Ariizumi T, Tabata K, Itakura Y, Kobayashi H, Hall W, Sasaki M PLoS Pathog. 2024; 20(3):e1012101.

PMID: 38502642 PMC: 10980201. DOI: 10.1371/journal.ppat.1012101.

Nairovirus polymerase mutations associated with the establishment of persistent infection in human cells.

Ohta K, Saka N, Nishi Y, Nishio M J Virol. 2024; 98(3):e0169823.

PMID: 38358288 PMC: 10949423. DOI: 10.1128/jvi.01698-23.

Characterisation of putative novel tick viruses and zoonotic risk prediction.

Lin Y, Pascall D Ecol Evol. 2024; 14(1):e10814.

PMID: 38259958 PMC: 10800298. DOI: 10.1002/ece3.10814.

Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays.

Tyrrell B, Kumar A, Gangadharan B, Alonzi D, Brun J, Hill M Pathogens. 2023; 12(3).

PMID: 36986321 PMC: 10057787. DOI: 10.3390/pathogens12030399.

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