PET Imaging of Inflammation Biomarkers

Overview

Journal Theranostics

Date 2013 Jul 12

PMID 23843893

Citations 76

Authors

Chenxi Wu

Fang Li

Gang Niu

Xiaoyuan Chen

Affiliations

Soon will be listed here.

Abstract

Inflammation plays a significant role in many disease processes. Development in molecular imaging in recent years provides new insight into the diagnosis and treatment evaluation of various inflammatory diseases and diseases involving inflammatory process. Positron emission tomography using (18)F-FDG has been successfully applied in clinical oncology and neurology and in the inflammation realm. In addition to glucose metabolism, a variety of targets for inflammation imaging are being discovered and utilized, some of which are considered superior to FDG for imaging inflammation. This review summarizes the potential inflammation imaging targets and corresponding PET tracers, and the applications of PET in major inflammatory diseases and tumor associated inflammation. Also, the current attempt in differentiating inflammation from tumor using PET is also discussed.

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References

Antonov A, Kolodgie F, Munn D, Gerrity R . Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis. Am J Pathol. 2004; 165(1):247-58. PMC: 1618536. DOI: 10.1016/s0002-9440(10)63293-2. View

Laitinen I, Luoto P, Nagren K, Marjamaki P, Silvola J, Hellberg S . Uptake of 11C-choline in mouse atherosclerotic plaques. J Nucl Med. 2010; 51(5):798-802. DOI: 10.2967/jnumed.109.071704. View

McCarthy T, Sheriff A, Graneto M, Talley J, Welch M . Radiosynthesis, in vitro validation, and in vivo evaluation of 18F-labeled COX-1 and COX-2 inhibitors. J Nucl Med. 2002; 43(1):117-24. View

Zhang W, Zhu X, Sun H, Xiong Y, Zhuang P, Xu H . Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects. Clin Cancer Res. 2010; 16(13):3420-30. DOI: 10.1158/1078-0432.CCR-09-2904. View

Edison P, Archer H, Gerhard A, Hinz R, Pavese N, Turkheimer F . Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study. Neurobiol Dis. 2008; 32(3):412-9. DOI: 10.1016/j.nbd.2008.08.001. View

Di Gialleonardo V, Signore A, Glaudemans A, Dierckx R, de Vries E . N-(4-18F-fluorobenzoyl)interleukin-2 for PET of human-activated T lymphocytes. J Nucl Med. 2012; 53(5):679-86. DOI: 10.2967/jnumed.111.091306. View

Matter C, Wyss M, Meier P, Spath N, von Lukowicz T, Lohmann C . 18F-choline images murine atherosclerotic plaques ex vivo. Arterioscler Thromb Vasc Biol. 2005; 26(3):584-9. DOI: 10.1161/01.ATV.0000200106.34016.18. View

de Vries E, van Waarde A, Buursma A, Vaalburg W . Synthesis and in vivo evaluation of 18F-desbromo-DuP-697 as a PET tracer for cyclooxygenase-2 expression. J Nucl Med. 2003; 44(10):1700-6. View

Zhu L, Wang H, Wang L, Wang Y, Jiang K, Li C . High-affinity peptide against MT1-MMP for in vivo tumor imaging. J Control Release. 2011; 150(3):248-55. PMC: 3085951. DOI: 10.1016/j.jconrel.2011.01.032. View

10.

Gaertner F, Kessler H, Wester H, Schwaiger M, Beer A . Radiolabelled RGD peptides for imaging and therapy. Eur J Nucl Med Mol Imaging. 2012; 39 Suppl 1:S126-38. DOI: 10.1007/s00259-011-2028-1. View

11.

Devinsky O, Vezzani A, Najjar S, de Lanerolle N, Rogawski M . Glia and epilepsy: excitability and inflammation. Trends Neurosci. 2013; 36(3):174-84. DOI: 10.1016/j.tins.2012.11.008. View

12.

Vandeputte C, Evens N, Toelen J, Deroose C, Bosier B, Ibrahimi A . A PET brain reporter gene system based on type 2 cannabinoid receptors. J Nucl Med. 2011; 52(7):1102-9. DOI: 10.2967/jnumed.110.084426. View

13.

Mertens K, Slaets D, Lambert B, Acou M, de Vos F, Goethals I . PET with (18)F-labelled choline-based tracers for tumour imaging: a review of the literature. Eur J Nucl Med Mol Imaging. 2010; 37(11):2188-93. DOI: 10.1007/s00259-010-1496-z. View

14.

Tezuka D, Haraguchi G, Ishihara T, Ohigashi H, Inagaki H, Suzuki J . Role of FDG PET-CT in Takayasu arteritis: sensitive detection of recurrences. JACC Cardiovasc Imaging. 2012; 5(4):422-9. DOI: 10.1016/j.jcmg.2012.01.013. View

15.

Chaudhari A, Bowen S, Burkett G, Packard N, Godinez F, Joshi A . High-resolution (18)F-FDG PET with MRI for monitoring response to treatment in rheumatoid arthritis. Eur J Nucl Med Mol Imaging. 2010; 37(5):1047. PMC: 2854399. DOI: 10.1007/s00259-009-1364-x. View

16.

Annovazzi A, Bonanno E, Arca M, DAlessandria C, Marcoccia A, Spagnoli L . 99mTc-interleukin-2 scintigraphy for the in vivo imaging of vulnerable atherosclerotic plaques. Eur J Nucl Med Mol Imaging. 2005; 33(2):117-26. DOI: 10.1007/s00259-005-1899-4. View

17.

Aziz M, Ishihara S, Mishima Y, Oshima N, Moriyama I, Yuki T . MFG-E8 attenuates intestinal inflammation in murine experimental colitis by modulating osteopontin-dependent alphavbeta3 integrin signaling. J Immunol. 2009; 182(11):7222-32. DOI: 10.4049/jimmunol.0803711. View

18.

Emelianov S, Li P, ODonnell M . Photoacoustics for molecular imaging and therapy. Phys Today. 2010; 62(8):34-39. PMC: 2879661. DOI: 10.1063/1.3141939. View

19.

Rosenbaum S, Lind T, Antoch G, Bockisch A . False-positive FDG PET uptake--the role of PET/CT. Eur Radiol. 2005; 16(5):1054-65. DOI: 10.1007/s00330-005-0088-y. View

20.

de Vries E, Doorduin J, Dierckx R, van Waarde A . Evaluation of [(11)C]rofecoxib as PET tracer for cyclooxygenase 2 overexpression in rat models of inflammation. Nucl Med Biol. 2007; 35(1):35-42. DOI: 10.1016/j.nucmedbio.2007.07.015. View