Establishment of a Lethal Mouse Model of Emerging Tick-borne Orthonairovirus Infections

Overview

Journal PLoS Pathog

Specialty Microbiology

Date 2024 Mar 19

PMID 38502642

Authors

Takuma Ariizumi

Koshiro Tabata

Yukari Itakura

Hiroko Kobayashi

William W Hall

Michihito Sasaki

Hirofumi Sawa

Keita Matsuno

Yasuko Orba

Affiliations

Soon will be listed here.

Abstract

Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we have established a mouse infection model using type-I/II interferon receptor-knockout mice (AG129 mice) both for a better understanding of the pathogenesis of these infections and validation of antiviral agents using Yezo virus (YEZV), a novel orthonairovirus causing febrile illnesses associated with tick bites in Japan and China. YEZV-inoculated AG129 mice developed hepatitis with body weight loss and died by 6 days post infection. Blood biochemistry tests showed elevated liver enzyme levels, similar to YEZV-infected human patients. AG129 mice treated with favipiravir survived lethal YEZV infection, demonstrating the anti-YEZV effect of this drug. The present mouse model will help us better understand the pathogenicity of the emerging tick-borne orthonairoviruses and the development of specific antiviral agents for their treatment.

Citing Articles

Isolation and characterization of Iwanai Valley virus, a new tick-borne nairovirus from Ixodes ovatus ticks in Hokkaido, Japan.

Matsumura R, Kobayashi D, Yamauchi T, Park E, Nishino A, Maeda K Arch Virol. 2024; 170(1):23.

PMID: 39708165 DOI: 10.1007/s00705-024-06195-0.

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