Surgical and Molecular Evaluation of Pediatric Hydatid Cyst Cases in Eastern Turkey

Overview

Journal Korean J Parasitol

Specialty Parasitology

Date 2016 Jan 23

PMID 26797450

Citations 9

Authors

Unal Bakal

Sami Simsek

Ahmet Kazez

Affiliations

Soon will be listed here.

Abstract

Cystic echinococcosis (CE) caused by Echinococcus granulosus is a major public health problem worldwide, including Turkey. The aim of the current study was to identify the strains and to estimate the potential risk factors of E. granulosus in operated pediatric cases in eastern Turkey. Ten pediatric patients (7 boys and 3 girls) living in rural areas, with ages ranging from 3 to 15 years old and various clinical histories, were included in this study. Eight patients had only liver hydatid cyst, while 1 patient had liver and lung hydatid cyst and the other liver, lung, and spleen, together. There were 2 ruptured liver cysts. After surgery, during follow-up, no increase was observed in hemagglutination levels, there were no mortalities, and there was no evidence of recurrence at 2 years post operation in all patients. Molecular analysis was performed on hydatid cyst samples obtained from the 10 pediatric cases. According to mt-12S rRNA PCR results, all cases were found to be G1/G3 cluster of E. granulosus sensu stricto.

Citing Articles

Cystic Echinococcosis in Hospitalized Children from Western Romania: A 25-Year Retrospective Study.

Paduraru A, Lupu M, Popoiu C, Stanciulescu M, Tirnea L, Boia E Biomedicines. 2024; 12(2).

PMID: 38397884 PMC: 10886803. DOI: 10.3390/biomedicines12020281.

Genetic diversity and haplotypes of paediatric hydatid cyst isolates and first occurrence of (G6/G7) in paediatric cases in Turkey.

Bakal U, Celik F, Simsek S, Kesik H, Kilinc S Parasitology. 2021; 148(12):1482-1489.

PMID: 34187611 PMC: 11010141. DOI: 10.1017/S0031182021001098.

Echinococcoses in Iran, Turkey, and Pakistan: Old Diseases in the New Millennium.

Borhani M, Fathi S, Darabi E, Jalousian F, Simsek S, Ahmed H Clin Microbiol Rev. 2021; 34(3):e0029020.

PMID: 34076492 PMC: 8262809. DOI: 10.1128/CMR.00290-20.

Human and animal cystic echinococcosis in Konya, Turkey: molecular identification and the first report of E. equinus from human host in Turkey.

Macin S, Orsten S, Samadzade R, Colak B, Cebeci H, Findik D Parasitol Res. 2021; 120(2):563-568.

PMID: 33462709 PMC: 7813620. DOI: 10.1007/s00436-021-07050-w.

Investigation of the relationship between CE cyst characteristics and genetic diversity of in humans from Turkey.

Orsten S, Ciftci T, Azizova A, Yuce G, Uysal A, Imamoglu C Parasitology. 2020; 147(14):1712-1717.

PMID: 32799957 PMC: 10317744. DOI: 10.1017/S0031182020001535.

References

Grosso G, Gruttadauria S, Biondi A, Marventano S, Mistretta A . Worldwide epidemiology of liver hydatidosis including the Mediterranean area. World J Gastroenterol. 2012; 18(13):1425-37. PMC: 3319938. DOI: 10.3748/wjg.v18.i13.1425. View

Simsek S, Kaplan M, Ozercan I . A comprehensive molecular survey of Echinococcus granulosus in formalin-fixed paraffin-embedded tissues in human isolates in Turkey. Parasitol Res. 2011; 109(2):411-6. DOI: 10.1007/s00436-011-2269-8. View

Aslanabadi S, Zarrintan S, Abdoli-Oskouei S, Salehpour F, Zarrintan A, Beheshtirouy S . Hydatid cyst in children: A 10-year experience from Iran. Afr J Paediatr Surg. 2013; 10(2):140-4. DOI: 10.4103/0189-6725.115040. View

Simsek S, Cevik A . First detection and molecular characterization of Echinococcus equinus in a mule in Turkey. Acta Parasitol. 2014; 59(4):773-7. DOI: 10.2478/s11686-014-0308-1. View

Giorgio A, Di Sarno A, de Stefano G, Liorre G, Farella N, Scognamiglio U . Sonography and clinical outcome of viable hydatid liver cysts treated with double percutaneous aspiration and ethanol injection as first-line therapy: efficacy and long-term follow-up. AJR Am J Roentgenol. 2009; 193(3):W186-92. DOI: 10.2214/AJR.08.1518. View

McManus D, Zhang W, Li J, Bartley P . Echinococcosis. Lancet. 2003; 362(9392):1295-304. DOI: 10.1016/S0140-6736(03)14573-4. View

Dinkel A, Njoroge E, Zimmermann A, Walz M, Zeyhle E, Elmahdi I . A PCR system for detection of species and genotypes of the Echinococcus granulosus-complex, with reference to the epidemiological situation in eastern Africa. Int J Parasitol. 2004; 34(5):645-53. DOI: 10.1016/j.ijpara.2003.12.013. View

Utuk A, Simsek S, Koroglu E, McManus D . Molecular genetic characterization of different isolates of Echinococcus granulosus in east and southeast regions of Turkey. Acta Trop. 2008; 107(2):192-4. DOI: 10.1016/j.actatropica.2008.05.026. View

Craig P, McManus D, Lightowlers M, Chabalgoity J, Garcia H, Gavidia C . Prevention and control of cystic echinococcosis. Lancet Infect Dis. 2007; 7(6):385-94. DOI: 10.1016/S1473-3099(07)70134-2. View

10.

Bryan R, Schantz P . Echinococcosis (hydatid disease). J Am Vet Med Assoc. 1989; 195(9):1214-7. View

11.

Snabel V, DAmelio S, Nakao M, Romig T, Yolasigmaz A, Gunes K . Cystic echinococcosis in Turkey: genetic variability and first record of the pig strain (G7) in the country. Parasitol Res. 2009; 105(1):145-54. DOI: 10.1007/s00436-009-1376-2. View

12.

Dopchiz M, Elissondo M, Andresiuk M, Maiorini E, Gutierrez A, Muzulin P . Pediatric hydatidosis in the south-east of the Buenos Aires province, Argentina. Rev Argent Microbiol. 2009; 41(2):105-11. View

13.

Santivanez S, Garcia H . Pulmonary cystic echinococcosis. Curr Opin Pulm Med. 2010; 16(3):257-61. PMC: 3362862. DOI: 10.1097/MCP.0b013e3283386282. View

14.

Simsek S, Balkaya I, Ciftci A, Utuk A . Molecular discrimination of sheep and cattle isolates of Echinococcus granulosus by SSCP and conventional PCR in Turkey. Vet Parasitol. 2011; 178(3-4):367-9. DOI: 10.1016/j.vetpar.2011.01.033. View

15.

Bakal U, Kazez A, Akyol M, Kocakoc E, Simsek S . A portable ultrasound based screening study on the prevalence and risk factors of cystic echinococcosis in primary school children in East Turkey. Acta Trop. 2012; 123(2):91-5. DOI: 10.1016/j.actatropica.2012.03.011. View