Long Non-coding RNA PCAT-1 Over-expression Promotes Proliferation and Metastasis in Non-small Cell Lung Cancer Cells

Overview

Journal Int J Clin Exp Med

Specialty General Medicine

Date 2016 Jan 16

PMID 26770456

Citations 32

Authors

Bing Zhao

Xiabao Hou

Hui Zhan

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (lncRNAs) have emerged as major players in governing fundamental biological processes, and play a functional role in tumorigenesis. Prostate cancer-associated transcript1 (PCAT-1) is a novel lncRNA that promotes cell proliferation in prostate cancer. However, the role of PCAT-1 on non-small cell lung cancer (NSCLC) remains unclear. In the present study, we firstly investigated PCAT-1 expression in NSCLC tissues and cell lines by using quantitative real-time PCR (QRT-PCR). Our results indicated that PCAT-1 was increased in NSCLC tissues and cell lines. PCAT-1 suppression using PCAT-1 small hairpin RNA (shRNA) with A549 cells inhibited cell proliferation, migration and invasion, while over-expression of PCAT-1 by synthetic plasmid vectors was shown to promote cell proliferation, migration and invasion. Our data suggested that PCAT-1 could play an oncogenic role in NSCLC progression. Silencing PCAT-1 is a potential novel therapeutic approach for lung cancer.

Citing Articles

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