Inducing Cell Growth Arrest and Apoptosis by Silencing Long Non-coding RNA PCAT-1 in Human Bladder Cancer

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2015 May 3

PMID 25934337

Citations 31

Authors

Li Liu

Yuchen Liu

Chengle Zhuang

Wen Xu

Xing Fu

Zhaojie Lv

Hanwei Wu

Lisha Mou

Guoping Zhao

Zhiming Cai

Weiren Huang

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs that play important roles in cancer development and progression. Prostate cancer-associated transcript 1 (PCAT-1) is a novel lncRNA that promotes cell proliferation in prostate cancer. We hypothesized that PCAT-1 also have roles in bladder cancer. In this study, we found that PCAT-1 was up-regulated in bladder cancer compared to paired normal urothelium. Cell proliferation inhibition and apoptosis induction were also observed in PCAT-1 small hairpin RNA (shRNA)-transfected bladder cancer T24 and 5637 cells. Our data suggest that PCAT-1 plays oncogenic roles and can be used as a therapeutic target for treating human bladder cancer.

Citing Articles

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