Antimicrobial Peptides and Wound Healing: Biological and Therapeutic Considerations

Overview

Journal Exp Dermatol

Specialty Dermatology

Date 2016 Jan 8

PMID 26738772

Citations 141

Authors

Maria Luisa Mangoni

Alison M McDermott

Michael Zasloff

Affiliations

Soon will be listed here.

Abstract

Repair of tissue wounds is a fundamental process to re-establish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host-defense molecules, including antimicrobial peptides (AMPs), aimed at controlling microbial proliferation and at modulating the host's immune response to a variety of biological or physical insults. In this brief review, we provide the evidence for a role of AMPs as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non-life-threatening skin and other epithelial injuries.

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