The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Dec 17

PMID 39684273

Authors

Xiaoyu Fan

Jinhong Ye

Wanling Zhong

Huijuan Shen

Huahua Li

Zhuyuan Liu

Jie Bai

Shouying Du

Affiliations

Soon will be listed here.

Abstract

The skin is the first line of defense to protect the host from external environmental damage. When the skin is damaged, the wound provides convenience for the invasion of external substances. The prolonged nonhealing of wounds can also lead to numerous subsequent complications, seriously affecting the quality of life of patients. To solve this problem, proteins and peptide components that promote wound healing have been discovered in animals, which can act on key pathways involved in wound healing, such as the PI3K/AKT, TGF-β, NF-κ B, and JAK/STAT pathways. So far, some formulations for topical drug delivery have been developed, including hydrogels, microneedles, and electrospinning nanofibers. In addition, some high-performance dressings have been utilized, which also have great potential in wound healing. Here, research progress on the promotion of wound healing by animal-derived proteins and peptide components is summarized, and future research directions are discussed.

References

Liu H, Duan Z, Tang J, Lv Q, Rong M, Lai R . A short peptide from frog skin accelerates diabetic wound healing. FEBS J. 2014; 281(20):4633-43. DOI: 10.1111/febs.12968. View

Zheng Z, Li M, Jiang P, Sun N, Lin S . Peptides derived from sea cucumber accelerate cells proliferation and migration for wound healing by promoting energy metabolism and upregulating the ERK/AKT pathway. Eur J Pharmacol. 2022; 921:174885. DOI: 10.1016/j.ejphar.2022.174885. View

Qiu L, Jin X, Xiang D, Fu Y, Tian X . [Study on the collagen constitution of hyperplastic scar in different ages and its influencing factors]. Zhonghua Shao Shang Za Zhi. 2003; 19(4):236-40. View

Gonzalez-Restrepo D, Zuluaga-Velez A, Orozco L, Sepulveda-Arias J . Silk fibroin-based dressings with antibacterial and anti-inflammatory properties. Eur J Pharm Sci. 2024; 195:106710. DOI: 10.1016/j.ejps.2024.106710. View

Yu T, Gao M, Yang P, Liu D, Wang D, Song F . Insulin promotes macrophage phenotype transition through PI3K/Akt and PPAR-γ signaling during diabetic wound healing. J Cell Physiol. 2018; 234(4):4217-4231. DOI: 10.1002/jcp.27185. View

Amani H, Shahbazi M, DAmico C, Fontana F, Abbaszadeh S, Santos H . Microneedles for painless transdermal immunotherapeutic applications. J Control Release. 2020; 330:185-217. DOI: 10.1016/j.jconrel.2020.12.019. View

Almaaytah A, Albalas Q . Scorpion venom peptides with no disulfide bridges: a review. Peptides. 2013; 51:35-45. DOI: 10.1016/j.peptides.2013.10.021. View

Griffin D, Weaver W, Scumpia P, Di Carlo D, Segura T . Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks. Nat Mater. 2015; 14(7):737-44. PMC: 4615579. DOI: 10.1038/nmat4294. View

Ghanbari Mehrabani M, Karimian R, Rakhshaei R, Pakdel F, Eslami H, Fakhrzadeh V . Chitin/silk fibroin/TiO bio-nanocomposite as a biocompatible wound dressing bandage with strong antimicrobial activity. Int J Biol Macromol. 2018; 116:966-976. DOI: 10.1016/j.ijbiomac.2018.05.102. View

10.

Cai G, Li R, Chai X, Cai X, Zheng K, Wang Y . Catalase-templated nanozyme-loaded microneedles integrated with polymyxin B for immunoregulation and antibacterial activity in diabetic wounds. J Colloid Interface Sci. 2024; 667:529-542. DOI: 10.1016/j.jcis.2024.04.121. View

11.

Jere S, Abrahamse H, Houreld N . The JAK/STAT signaling pathway and photobiomodulation in chronic wound healing. Cytokine Growth Factor Rev. 2017; 38:73-79. DOI: 10.1016/j.cytogfr.2017.10.001. View

12.

Ruszczak Z . Effect of collagen matrices on dermal wound healing. Adv Drug Deliv Rev. 2003; 55(12):1595-611. DOI: 10.1016/j.addr.2003.08.003. View

13.

Feng G, Wei L, Che H, Shen Y, Yang J, Mi K . A Frog Peptide Ameliorates Skin Photoaging Through Scavenging Reactive Oxygen Species. Front Pharmacol. 2022; 12:761011. PMC: 8807480. DOI: 10.3389/fphar.2021.761011. View

14.

Du Q, Hou X, Ge L, Li R, Zhou M, Wang H . Cationicity-enhanced analogues of the antimicrobial peptides, AcrAP1 and AcrAP2, from the venom of the scorpion, Androctonus crassicauda, display potent growth modulation effects on human cancer cell lines. Int J Biol Sci. 2014; 10(10):1097-107. PMC: 4202026. DOI: 10.7150/ijbs.9859. View

15.

Herrington F, Carmody R, Goodyear C . Modulation of NF-κB Signaling as a Therapeutic Target in Autoimmunity. J Biomol Screen. 2015; 21(3):223-42. DOI: 10.1177/1087057115617456. View

16.

Mndlovu H, du Toit L, Kumar P, Choonara Y, Marimuthu T, Kondiah P . Bioplatform Fabrication Approaches Affecting Chitosan-Based Interpolymer Complex Properties and Performance as Wound Dressings. Molecules. 2020; 25(1). PMC: 6982769. DOI: 10.3390/molecules25010222. View

17.

Natsheh H, Touitou E . Phospholipid Vesicles for Dermal/Transdermal and Nasal Administration of Active Molecules: The Effect of Surfactants and Alcohols on the Fluidity of Their Lipid Bilayers and Penetration Enhancement Properties. Molecules. 2020; 25(13). PMC: 7412180. DOI: 10.3390/molecules25132959. View

18.

Kumar M, Mahmood S, Chopra S, Bhatia A . Biopolymer based nanoparticles and their therapeutic potential in wound healing - A review. Int J Biol Macromol. 2024; 267(Pt 2):131335. DOI: 10.1016/j.ijbiomac.2024.131335. View

19.

Seykora J, Dentchev T, Margolis D . Filaggrin-2 barrier protein inversely varies with skin inflammation. Exp Dermatol. 2015; 24(9):720-2. PMC: 4547533. DOI: 10.1111/exd.12749. View

20.

Balamurugan M, Parthasarathi K, Ranganathan L, Cooper E . Hypothetical mode of action of earthworm extract with hepatoprotective and antioxidant properties. J Zhejiang Univ Sci B. 2008; 9(2):141-7. PMC: 2225496. DOI: 10.1631/jzus.B0720194. View