Correcting for Respiratory Motion in Liver PET/MRI: Preliminary Evaluation of the Utility of Bellows and Navigated Hepatobiliary Phase Imaging

Overview

Journal EJNMMI Phys

Specialty Radiology

Date 2015 Oct 27

PMID 26501822

Citations 8

Authors

Thomas A Hope

Emily F Verdin

Emily K Bergsland

Michael A Ohliger

Carlos U Corvera

Eric K Nakakura

Affiliations

Soon will be listed here.

Abstract

Background: The purpose of this study was to evaluate the utility of bellows-based respiratory compensation and navigated hepatobiliary phase imaging to correct for respiratory motion in the setting of dedicated liver PET/MRI.

Methods: Institutional review board approval and informed consent were obtained. Six patients with metastatic neuroendocrine tumor were imaged using Ga-68 DOTA-TOC PET/MRI. Whole body imaging and a dedicated 15-min liver PET acquisition was performed, in addition to navigated and breath-held hepatobiliary phase (HBP) MRI. Liver PET data was reconstructed three ways: the entire data set (liver PET), gated using respiratory bellows (RC-liver PET), and a non-gated data set reconstructed using the same amount of data used in the RC-liver PET (shortened liver PET). Liver lesions were evaluated using SUVmax, SUVpeak, SUVmean, and Volisocontour. Additionally, the displacement of each lesion between the RC-liver PET images and the navigated and breath-held HBP images was calculated.

Results: Respiratory compensation resulted in a 43 % increase in SUVs compared to ungated data (liver vs RC-liver PET SUVmax 26.0 vs 37.3, p < 0.001) and a 25 % increase compared to a non-gated reconstruction using the same amount of data (RC-liver vs shortened liver PET SUVmax 26.0 vs 32.6, p < 0.001). Lesion displacement was minimized using navigated HBP MRI (1.3 ± 1.0 mm) compared to breath-held HBP MRI (23.3 ± 1.0 mm).

Conclusions: Respiratory bellows can provide accurate respiratory compensation when imaging liver lesions using PET/MRI, and results in increased SUVs due to a combination of increased image noise and reduced respiratory blurring. Additionally, navigated HBP MRI accurately aligns with respiratory compensated PET data.

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