» Articles » PMID: 26322042

A Hitchhiker's Guide to Myeloid Cell Subsets: Practical Implementation of a Novel Mononuclear Phagocyte Classification System

Overview
Journal Front Immunol
Date 2015 Sep 1
PMID 26322042
Citations 64
Authors
Affiliations
Soon will be listed here.
Abstract

The classification of mononuclear phagocytes as either dendritic cells or macrophages has been mainly based on morphology, the expression of surface markers, and assumed functional specialization. We have recently proposed a novel classification system of mononuclear phagocytes based on their ontogeny. Here, we discuss the practical application of such a classification system through a number of prototypical examples we have encountered while hitchhiking from one subset to another, across species and between steady-state and inflammatory settings. Finally, we discuss the advantages and drawbacks of such a classification system and propose a number of improvements to move from theoretical concepts to concrete guidelines.

Citing Articles

Saponin-based adjuvant uptake and induction of antigen cross-presentation by CD11b+ dendritic cells and macrophages.

Huis In t Veld L, Cornelissen L, van den Bogaard L, Ansems M, Ho N, Adema G NPJ Vaccines. 2025; 10(1):15.

PMID: 39843492 PMC: 11754886. DOI: 10.1038/s41541-024-01056-y.


Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma.

Ullah M, Rittchen S, Li J, Curren B, Namubiru P, Ahmed T Nat Commun. 2024; 15(1):10253.

PMID: 39592603 PMC: 11599388. DOI: 10.1038/s41467-024-54670-8.


Macrophages in tissue repair and regeneration: insights from zebrafish.

Zhao C, Yang Z, Li Y, Wen Z Cell Regen. 2024; 13(1):12.

PMID: 38861103 PMC: 11166613. DOI: 10.1186/s13619-024-00195-w.


Amniotic fluid stem cell-derived extracellular vesicles educate type 2 conventional dendritic cells to rescue autoimmune disorders in a multiple sclerosis mouse model.

Manni G, Gargaro M, Ricciuti D, Fontana S, Padiglioni E, Cipolloni M J Extracell Vesicles. 2024; 13(6):e12446.

PMID: 38844736 PMC: 11156524. DOI: 10.1002/jev2.12446.


Non-Tumor Cells within the Tumor Microenvironment-The "Eminence Grise" of the Glioblastoma Pathogenesis and Potential Targets for Therapy.

Bugakova A, Chudakova D, Myzina M, Yanysheva E, Ozerskaya I, Soboleva A Cells. 2024; 13(10.

PMID: 38786032 PMC: 11119139. DOI: 10.3390/cells13100808.


References
1.
Satpathy A, Briseno C, Lee J, Ng D, Manieri N, Kc W . Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol. 2013; 14(9):937-48. PMC: 3788683. DOI: 10.1038/ni.2679. View

2.
Kuipers H, Soullie T, Hammad H, Willart M, Kool M, Hijdra D . Sensitization by intratracheally injected dendritic cells is independent of antigen presentation by host antigen-presenting cells. J Leukoc Biol. 2008; 85(1):64-70. DOI: 10.1189/jlb.0807519. View

3.
Crozat K, Tamoutounour S, Vu Manh T, Fossum E, Luche H, Ardouin L . Cutting edge: expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8α+ type. J Immunol. 2011; 187(9):4411-5. DOI: 10.4049/jimmunol.1101717. View

4.
Bachem A, Hartung E, Guttler S, Mora A, Zhou X, Hegemann A . Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation. Front Immunol. 2012; 3:214. PMC: 3399095. DOI: 10.3389/fimmu.2012.00214. View

5.
Palucka K, Taquet N, Gluckman J . Dendritic cells as the terminal stage of monocyte differentiation. J Immunol. 1998; 160(9):4587-95. View