The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

Overview

Journal Annu Rev Immunol

Specialty Allergy & Immunology

Date 2013 Mar 23

PMID 23516985

Citations 1165

Authors

Miriam Merad

Priyanka Sathe

Julie Helft

Jennifer Miller

Arthur Mortha

Affiliations

Soon will be listed here.

Abstract

Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.

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