Immunopathology of Multiple Sclerosis

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2015 Aug 8

PMID 26250739

Citations 968

Authors

Calliope A Dendrou

Lars Fugger

Manuel A Friese

Affiliations

Soon will be listed here.

Abstract

Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis point to distinct immunological pathways that drive disease relapses and progression. In light of this, we discuss our current understanding of multiple sclerosis immunopathology, evaluate long-standing hypotheses regarding the role of the immune system in the disease and delineate key questions that are still unanswered. Recent and anticipated advances in the field of immunology, and the increasing recognition of inflammation as an important component of neurodegeneration, are shaping our conceptualization of disease pathophysiology, and we explore the potential implications for improved healthcare provision to patients in the future.

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