Role of Innate Immune Cells in Multiple Sclerosis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2025 Mar 4

PMID 40034690

Authors

Carolina Prado

Andres A Herrada

Daniel Hevia

Lorna Galleguillos Goiry

Noelia Escobedo

Affiliations

Soon will be listed here.

Abstract

Multiple sclerosis (MS) is a chronic autoimmune, inflammatory and neurodegenerative disease affecting the central nervous system (CNS). MS is associated with a complex interplay between neurodegenerative and inflammatory processes, mostly attributed to pathogenic T and B cells. However, a growing body of preclinical and clinical evidence indicates that innate immunity plays a crucial role in MS promotion and progression. Accordingly, preclinical and clinical studies targeting different innate immune cells to control MS are currently under study, highlighting the importance of innate immunity in this pathology. Here, we reviewed recent findings regarding the role played by innate immune cells in the pathogenesis of MS. Additionally, we discuss potential new treatments for MS based on targets against innate immune components.

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