Downregulation of Long Noncoding RNA MALAT1 Induces Epithelial-to-mesenchymal Transition Via the PI3K-AKT Pathway in Breast Cancer

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2015 Jul 21

PMID 26191181

Citations 78

Authors

Shouping Xu

Shiyao Sui

Jinfeng Zhang

Nanxia Bai

Qingyu Shi

Guangwen Zhang

Song Gao

Zilong You

Chao Zhan

Feng Liu

Da Pang

Affiliations

Soon will be listed here.

Abstract

The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) regulates cell motility via the transcriptional or post-transcriptional control of motility-related genes. Whether MALAT1 plays a critical role in cancer progression in breast cancer remains unclear. In this study, we found that MALAT1 was downregulated in breast tumor cell lines and cancer tissue, and showed that knockdown of MALAT1 in breast cancer cell lines induced an epithelial-to-mesenchymal transition (EMT) program via phosphatidylinositide-3 kinase-AKT pathways. Furthermore, lower expression of MALAT1 in breast cancer patients was associated with shorter relapse-free survival. Thus, our results indicate for the first time that MALAT1 is a novel regulator of EMT in breast cancer and may be a potential therapeutic target for breast cancer metastasis.

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