Analysis of the Regulation of Metastasis-associated Lung Adenocarcinoma Transcript 1 on the Biological Behavior of Breast Cancer

Overview

Journal Transl Cancer Res

Specialty Oncology

Date 2022 Feb 4

PMID 35116487

Authors

Xiao He

Qinfang Miao

Yi Yi

Weijie Hu

Min Wu

Yiping Wu

Qi Zhang

Affiliations

Soon will be listed here.

Abstract

Background: Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a class of long non-coding RNA (lncRNA) that has been proved to be closely related to many cancers.

Methods: The relevant research on MALAT1 in cancers published in recent years were collected and integrated. CiteSpace was employed to draw a knowledge map of MALAT1 in breast cancer, to evaluate the research front-burner issues. Then, multiple microarray data sets were searched from online data for meta-analysis to evaluate the relationship between MALAT1 and breast cancer survival rate.

Results: The results showed that MALAT1 had been widely studied in the proliferation and differentiation of cancer cells, and MALAT1 might regulate breast cancer through the PI3K/AKT/mTOR signaling pathway. In addition, high expression of MALAT1 had a significant correlation with relapse-free survival (HR: 1.51, 95% CI: 0.79-2.29), while there was no significant correlation between MALAT1 expression and overall survival (HR: 1.09, 95% CI: 0.63-1.72).

Conclusions: The expression level of lncRNA MALAT1 was closely related to cancer progression and prognosis of cancer patients. Moreover, the expression of MALAT1 was strongly associated with the survival rate of recurrence-free breast cancer. However, since the present study only adopted the existing literature for visual analysis, subsequent experiments are needed to be done to verify this conclusion. It is hoped that this work could provide a theoretical foundation for promoting the clinical adoption of MALAT1 in the prediction, diagnosis, and treatment of breast cancer, and point out a new direction for the in-depth exploration of the function of MALAT1.

Citing Articles

Prognostic and diagnostic values of non-coding RNAs as biomarkers for breast cancer: An umbrella review and pan-cancer analysis.

Bahramy A, Zafari N, Rajabi F, Aghakhani A, Jayedi A, Khaboushan A Front Mol Biosci. 2023; 10:1096524.

PMID: 36726376 PMC: 9885171. DOI: 10.3389/fmolb.2023.1096524.

References

Takele Assefa A, De Paepe K, Everaert C, Mestdagh P, Thas O, Vandesompele J . Differential gene expression analysis tools exhibit substandard performance for long non-coding RNA-sequencing data. Genome Biol. 2018; 19(1):96. PMC: 6058388. DOI: 10.1186/s13059-018-1466-5. View

Egger S, Bachmann A, Hubmann N, Schlienger R, Krahenbuhl S . Prevalence of potentially inappropriate medication use in elderly patients: comparison between general medical and geriatric wards. Drugs Aging. 2006; 23(10):823-37. DOI: 10.2165/00002512-200623100-00005. View

Arun G, Diermeier S, Akerman M, Chang K, Wilkinson J, Hearn S . Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. Genes Dev. 2015; 30(1):34-51. PMC: 4701977. DOI: 10.1101/gad.270959.115. View

Xu S, Sui S, Zhang J, Bai N, Shi Q, Zhang G . Downregulation of long noncoding RNA MALAT1 induces epithelial-to-mesenchymal transition via the PI3K-AKT pathway in breast cancer. Int J Clin Exp Pathol. 2015; 8(5):4881-91. PMC: 4503053. View

Gutschner T, Hammerle M, Eissmann M, Hsu J, Kim Y, Hung G . The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res. 2012; 73(3):1180-9. PMC: 3589741. DOI: 10.1158/0008-5472.CAN-12-2850. View

Xiao Y, Pan J, Geng Q, Wang G . LncRNA MALAT1 increases the stemness of gastric cancer cells via enhancing SOX2 mRNA stability. FEBS Open Bio. 2019; 9(7):1212-1222. PMC: 6609564. DOI: 10.1002/2211-5463.12649. View

Gutschner T, Hammerle M, Diederichs S . MALAT1 -- a paradigm for long noncoding RNA function in cancer. J Mol Med (Berl). 2013; 91(7):791-801. DOI: 10.1007/s00109-013-1028-y. View

Gupta R, Arany Z, Seale P, Mepani R, Ye L, Conroe H . Transcriptional control of preadipocyte determination by Zfp423. Nature. 2010; 464(7288):619-23. PMC: 2845731. DOI: 10.1038/nature08816. View

Jin Y, Feng S, Qiu S, Shao N, Zheng J . LncRNA MALAT1 promotes proliferation and metastasis in epithelial ovarian cancer via the PI3K-AKT pathway. Eur Rev Med Pharmacol Sci. 2017; 21(14):3176-3184. View

10.

Yang H, Wang S, Kang Y, Wang C, Xu Y, Zhang Y . Long non-coding RNA SNHG1 predicts a poor prognosis and promotes colon cancer tumorigenesis. Oncol Rep. 2018; 40(1):261-271. PMC: 6059747. DOI: 10.3892/or.2018.6412. View

11.

Kwong J, Schwartz K, Campitelli M, Chung H, Crowcroft N, Karnauchow T . Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection. N Engl J Med. 2018; 378(4):345-353. DOI: 10.1056/NEJMoa1702090. View

12.

Yang L, Lin C, Liu W, Zhang J, Ohgi K, Grinstein J . ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell. 2011; 147(4):773-88. PMC: 3297197. DOI: 10.1016/j.cell.2011.08.054. View

13.

Jathar S, Kumar V, Srivastava J, Tripathi V . Technological Developments in lncRNA Biology. Adv Exp Med Biol. 2017; 1008:283-323. DOI: 10.1007/978-981-10-5203-3_10. View

14.

Sun Z, Liu J, Liu J . The expression of lncRNA-MALAT1 in breast cancer patients and its influences on prognosis. Cell Mol Biol (Noisy-le-grand). 2020; 66(3):72-78. View

15.

Lei L, Zeng Q, Lu J, Ding S, Xia F, Kang J . MALAT1 participates in ultraviolet B-induced photo-aging via regulation of the ERK/MAPK signaling pathway. Mol Med Rep. 2017; 15(6):3977-3982. PMC: 5436239. DOI: 10.3892/mmr.2017.6532. View

16.

Kim J, Piao H, Kim B, Yao F, Han Z, Wang Y . Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 2018; 50(12):1705-1715. PMC: 6265076. DOI: 10.1038/s41588-018-0252-3. View

17.

Zheng H, Shi D, Wang Y, Li X, Xu Y, Tripathi P . High expression of lncRNA MALAT1 suggests a biomarker of poor prognosis in colorectal cancer. Int J Clin Exp Pathol. 2014; 7(6):3174-81. PMC: 4097248. View

18.

Zhang H, Yang F, Chen S, Che J, Zheng J . Upregulation of long non-coding RNA MALAT1 correlates with tumor progression and poor prognosis in clear cell renal cell carcinoma. Tumour Biol. 2014; 36(4):2947-55. DOI: 10.1007/s13277-014-2925-6. View

19.

Hirata H, Hinoda Y, Shahryari V, Deng G, Nakajima K, Tabatabai Z . Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205. Cancer Res. 2015; 75(7):1322-31. PMC: 5884967. DOI: 10.1158/0008-5472.CAN-14-2931. View

20.

Peterson A, Bond G, Drake R, McHugo G, Jones A, Williams J . Predicting the long-term sustainability of evidence-based practices in mental health care: an 8-year longitudinal analysis. J Behav Health Serv Res. 2013; 41(3):337-46. DOI: 10.1007/s11414-013-9347-x. View