First Report of an OXA-48-producing Multidrug-resistant Proteus Mirabilis Strain from Gaza, Palestine

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2015 Apr 22

PMID 25896692

Citations 24

Authors

Liang Chen

Nahed Al Laham

Kalyan D Chavda

Jose R Mediavilla

Michael R Jacobs

Robert A Bonomo

Barry N Kreiswirth

Affiliations

Soon will be listed here.

Abstract

We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to β-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complete sequencing of the bla(OXA-48)-harboring plasmid revealed that it is a 72 kb long IncL/M plasmid, harboring carbapenemase gene bla(OXA-48), extended spectrum β-lactamase gene bla(CTX-M-14), and aminoglycoside resistance genes strA, strB, and aph(3')-VIb.

Citing Articles

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