Hyperspectral Time-resolved Wide-field Fluorescence Molecular Tomography Based on Structured Light and Single-pixel Detection

Overview

Journal Opt Lett

Specialty Ophthalmology

Date 2015 Feb 14

PMID 25680065

Citations 27

Authors

Qi Pian

Ruoyang Yao

Lingling Zhao

Xavier Intes

Affiliations

Soon will be listed here.

Abstract

We present a time-resolved fluorescence diffuse optical tomography platform that is based on wide-field structured illumination, single-pixel detection, and hyperspectral acquisition. Two spatial light modulators (digital micro-mirror devices) are employed to generate independently wide-field illumination and detection patterns, coupled with a 16-channel spectrophotometer detection module to capture hyperspectral time-resolved tomographic data sets. The main system characteristics are reported, and we demonstrate the feasibility of acquiring dense 4D tomographic data sets (space, time, spectra) for time domain 3D quantitative multiplexed fluorophore concentration mapping in turbid media.

Citing Articles

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Deep learning-based fusion of widefield diffuse optical tomography and micro-CT structural priors for accurate 3D reconstructions.

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