Review of Structured Light in Diffuse Optical Imaging
Overview
Ophthalmology
Affiliations
Diffuse optical imaging probes deep living tissue enabling structural, functional, metabolic, and molecular imaging. Recently, due to the availability of spatial light modulators, wide-field quantitative diffuse optical techniques have been implemented, which benefit greatly from structured light methodologies. Such implementations facilitate the quantification and characterization of depth-resolved optical and physiological properties of thick and deep tissue at fast acquisition speeds. We summarize the current state of work and applications in the three main techniques leveraging structured light: spatial frequency-domain imaging, optical tomography, and single-pixel imaging. The theory, measurement, and analysis of spatial frequency-domain imaging are described. Then, advanced theories, processing, and imaging systems are summarized. Preclinical and clinical applications on physiological measurements for guidance and diagnosis are summarized. General theory and method development of tomographic approaches as well as applications including fluorescence molecular tomography are introduced. Lastly, recent developments of single-pixel imaging methodologies and applications are reviewed.
Widefield ultra-high-density optical breast tomography system supplementing x-ray mammography.
Mireles M, Xu E, Vanegas M, Muldoon A, Ragunathan R, Yan S Sci Rep. 2025; 15(1):8732.
PMID: 40082492 PMC: 11906649. DOI: 10.1038/s41598-025-92261-9.
Medium-adaptive compressive diffuse optical tomography.
Mireles M, Xu E, Ragunathan R, Fang Q Biomed Opt Express. 2024; 15(9):5128-5142.
PMID: 39296389 PMC: 11407237. DOI: 10.1364/BOE.529195.
Walter A, Jansen E J Biomed Opt. 2024; 29(9):095001.
PMID: 39247057 PMC: 11379407. DOI: 10.1117/1.JBO.29.9.095001.
Ren W, Ni R Methods Mol Biol. 2024; 2785:271-285.
PMID: 38427199 DOI: 10.1007/978-1-0716-3774-6_16.
Development of a glass-based imaging phantom to model the optical properties of human tissue.
Yang M, Wei Y, Reineck P, Ebendorff-Heidepriem H, Li J, McLaughlin R Biomed Opt Express. 2024; 15(1):346-359.
PMID: 38223187 PMC: 10783914. DOI: 10.1364/BOE.504774.