Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells

Overview

Journal Adv Mater

Date 2015 Feb 3

PMID 25640006

Citations 51

Authors

Eduardo Reategui

Nicola Aceto

Eugene J Lim

James P Sullivan

Anne E Jensen

Mahnaz Zeinali

Joseph M Martel

Alexander J Aranyosi

Wei Li

Steven Castleberry

Aditya Bardia

Lecia V Sequist

Daniel A Haber

Shyamala Maheswaran

Paula T Hammond

Mehmet Toner

Shannon L Stott

Affiliations

Soon will be listed here.

Abstract

A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.

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