Steven Castleberry
Overview
Explore the profile of Steven Castleberry including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
128
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0
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Recent Articles
1.
Kordorwu V, Castleberry S, Lustig S, Carrier R
Mol Pharm
. 2025 Feb;
22(3):1396-1407.
PMID: 39977612
Many drugs entering clinical trials today are poorly water-soluble and rely on supersaturating formulations, such as amorphous solid dispersions (ASD) to enhance their bioavailability. The performance of these formulations is...
2.
Nespi M, Ly J, Fan Y, Chen S, Liu L, Gu Y, et al.
J Pharm Sci
. 2024 Nov;
114(1):566-576.
PMID: 39486520
In early drug development, amorphous spray-dried dispersions (SDDs) applied to enhance the bioavailability of poorly water-soluble compounds are typically administered to preclinical species via oral gavage in the form of...
3.
Shujan Ali M, Castleberry S
Int J Pharm
. 2023 Dec;
651:123752.
PMID: 38159584
One of the most common reported adverse events for intravenous (IV) infusions are infusion site reactions, ranging from redness and pain at the site of infusion to thrombophlebitis. The connection...
4.
Ramasubramanian H, Castleberry S
Mol Pharm
. 2023 Mar;
20(5):2726-2737.
PMID: 36999656
In preclinical drug discovery, simple fraction absorbed calculators are exceptionally valuable tools to better understand the potential limitations to drug absorption and how different formulation approaches may address them. These...
5.
Castleberry S
Int J Pharm
. 2023 Mar;
636:122807.
PMID: 36898620
There are a number of obstacles that complicate the development of intravitreal delivered small molecules therapies. One serious complication is the potential need for complex polymer depot formulations early in...
6.
Fan Y, Castleberry S
Int J Pharm
. 2022 Dec;
631:122495.
PMID: 36526147
Many poorly water-soluble active pharmaceutical ingredients (APIs) rely on supersaturating formulations, such as amorphous solid dispersions (ASDs), to enhance oral bioavailability. ASDs kinetically trap amorphous solid drugs within polymer excipient...
7.
Characterization of the Hydrodynamics in the USP Basket Apparatus Using Computational Fluid Dynamics
Martinez A, Sinha K, Nere N, Slade R, Castleberry S
J Pharm Sci
. 2019 Nov;
109(3):1231-1241.
PMID: 31743682
Computational fluid dynamics (CFD) has been extensively used for the USP paddle apparatus II, but limited CFD studies have been conducted on the USP basket apparatus I. We expanded on...
8.
Emami Riedmaier A, Lindley D, Hall J, Castleberry S, Slade R, Stuart P, et al.
J Pharm Sci
. 2017 Oct;
107(1):495-502.
PMID: 28993217
Venetoclax, a selective B-cell lymphoma-2 inhibitor, is a biopharmaceutics classification system class IV compound. The aim of this study was to develop a physiologically based pharmacokinetic (PBPK) model to mechanistically...
9.
Dong Z, Tang L, Ahrens C, Ding Z, Cao V, Castleberry S, et al.
Lab Chip
. 2016 Oct;
16(23):4601-4611.
PMID: 27785506
Capillary flow layer-by-layer (CF-LbL) is a microfluidic platform for high throughput preparation and screening of nanolayered polymer films. Using a simple benchtop version of CF-LbL, we systematically studied the effects...
10.
Fritts S, Moorman C, Grodsky S, Hazel D, Homyack J, Farrell C, et al.
Ecol Appl
. 2016 Jul;
26(3):926-39.
PMID: 27411261
Forests are a major supplier of renewable energy; however, gleaning logging residues for use as woody biomass feedstock could negatively alter habitat for species dependent on downed wood. Biomass Harvesting...